State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …

Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields
have been combined only recently to facilitate novel experiments and measurements in …

Tissue clearing technique enables visualization of opaque organs and tissues in 3-
dimensions (3-D) by turning tissue transparent. Current tissue clearing methods are …

Tissue-clearing techniques are powerful tools for biological research and pathological
diagnosis. Here, we describe advanced clear, unobstructed brain imaging cocktails and …

Optical coherence tomography (herein “OCT”) based analyte monitoring systems are
disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (eg …

Every optical imaging technique is limited in its penetration depth by scattering occurring in
biological tissues. Possible solutions to overcome this problem consist of limiting the …

This tutorial-review introduces the fundamentals of polarized light interaction with biological
tissues and presents some of the recent key polarization optical methods that have made …

Organisms are inherently three dimensional, thus comprehensive understanding of the
complicated biological system requires analysis of organs or even whole bodies in the …

Organism-level systems biology aims to identify, analyze, control and design cellular circuits
in organisms. Many experimental and computational approaches have been developed …

A method for noninvasively measuring analyte levels includes using a non-imaging OCT-
based system to scan a two-dimensional area of biological tissue and gather data …