Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

The circuitry within the thalamus creates an intrinsic oscillatory unit whose function depends
critically on reciprocal synaptic connectivity between excitatory thalamocortical relay …

The ketogenic diet (KD) has been used for a long time as a therapeutic approach for drug-
resistant epilepsy. It is a high-fat, low-carbohydrate, and adequate protein diet. There are …

Epilepsy is a common neurological disorder characterized by recurrent seizures. These
seizures are due to abnormal excessive and synchronous neuronal activity in the brain …

Temporal lobe epilepsy remains amongst the most common and drug refractory of
neurological disorders. Gene therapy may provide a realistic therapeutic approach …

Epilepsy is a chronic and debilitating neurological disorder, with a worldwide prevalence of
0.5–1% and a lifetime incidence of 1–3%. An estimated 30% of epileptic patients continue to …

Neuropeptides play an important role in modulating seizures and epilepsy. Unlike
neurotransmitters which operate on a millisecond time-scale, neuropeptides have longer …

The aim of epilepsy treatment is to achieve complete seizure freedom. Nonetheless,
numerous side effects and seizure resistance to antiepileptic drugs (AEDs) affecting about …

Recombinant adeno-associated virus (rAAV) is derived from a small human parvovirus with
an excellent safety profile. In addition, this viral vector efficiently transduces and supports …

Leptin is a hormone that reduces excitability in some hypothalamic neurons via leptin
receptor activation of the JAK2 and PI3K intracellular signaling pathways. We hypothesized …