Because burn injuries are often followed by a derailed immune response and excessive
inflammation, a thorough understanding of the occurring reactions is key to preventing …

Associated with the development of hospital-acquired infections, major traumatic injury
results in an immediate and persistent state of systemic immunosuppression, yet the …

Severe burns threaten patient lives due to pain, inflammation, bacterial infection, and
scarring. Most burn dressings that are commonly used perform a single function and are not …

Severe or major burns induce a pathophysiological, immune, and inflammatory response
that can persist for a long time and affect morbidity and mortality. Severe burns are followed …

Abstract Leucine-rich alpha-2-glycoprotein-1 (LRG1) has been shown to compete with
apoptosis activating factor-1 (Apaf-1) for binding cytochrome c (Cyt c) and could play a role …

Abstract The NLRP3 (NOD‐, LRR‐, and pyrin domain‐containing protein 3) inflammasome
is a multimeric protein complex that is engaged in the innate immune system and plays a …

Increased morbidity and mortality after polytrauma due to multiple organ failure (MOF) is a
major concern for clinicians. Systemic inflammatory response syndrome (SIRS) and sepsis …

A peripheral injury drives neuroimmune interactions at the level of the injury and throughout
the neuraxis. Understanding these systems will be beneficial in the pursuit to target …

The Earth's population is aging, and by 2050, one of six people will be 65 years or older.
Therefore, proper treatment of injuries that disproportionately impact people of advanced …

Introduction Thermal injury often leads to prolonged and excessive inflammation, which
hinders the recovery of patients. There is a notable absence of suitable animal-free models …