Traumatic brain injury (TBI) remains one of the most fatal and debilitating conditions in the
world. Current clinical management in severe TBI patients is mainly concerned with …

Viscoelastic hemostatic assay (VHAs) are whole blood point-of-care tests that have become
an essential method for assaying hemostatic competence in liver transplantation, cardiac …

Blood loss by hemorrhaging wounds accounts for over one-third of∼ 5 million trauma
fatalities worldwide every year. If not controlled in a timely manner, exsanguination can take …

Importance Critical bleeding is associated with a high mortality rate in patients with trauma.
Hemorrhage is exacerbated by a complex derangement of coagulation, including an acute …

The endothelial glycocalyx is a gel-like layer on the luminal side of blood vessels that is
composed of glycosaminoglycans and the proteins that tether them to the plasma …

Treatment of bleeding disorders using transfusion of donor-derived platelets faces logistical
challenges due to their limited availability, high risk of contamination, and short (5 to 7 days) …

Importance Blood transfusion is a mainstay of therapy for trauma-induced coagulopathy, but
the optimal modalities for plasma transfusion in the prehospital setting remain to be defined …

Hypothermia in trauma patients is a common condition. It is aggravated by traumatic
hemorrhage, which leads to hypovolemic shock. This hypovolemic shock results in a lethal …

Contemporary trauma care comprises advanced pre-hospital care, regionalized trauma
systems, damage control operative techniques, advanced critical care, rehabilitation with …

Earlier variants of SARS-CoV-2 have been associated with hypercoagulability and an
extensive formation of fibrin amyloid microclots, which are considered to contribute to the …