Management of moderate to severe traumatic brain injury: an update for the intensivist
G Meyfroidt, P Bouzat, MP Casaer, R Chesnut… - Intensive care …, 2022 - Springer
Traumatic brain injury (TBI) remains one of the most fatal and debilitating conditions in the
world. Current clinical management in severe TBI patients is mainly concerned with …
world. Current clinical management in severe TBI patients is mainly concerned with …
Viscoelastic hemostatic assays: a primer on legacy and new generation devices
O Volod, CM Bunch, N Zackariya, EE Moore… - Journal of Clinical …, 2022 - mdpi.com
Viscoelastic hemostatic assay (VHAs) are whole blood point-of-care tests that have become
an essential method for assaying hemostatic competence in liver transplantation, cardiac …
an essential method for assaying hemostatic competence in liver transplantation, cardiac …
[HTML][HTML] Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment
Blood loss by hemorrhaging wounds accounts for over one-third of∼ 5 million trauma
fatalities worldwide every year. If not controlled in a timely manner, exsanguination can take …
fatalities worldwide every year. If not controlled in a timely manner, exsanguination can take …
Early and empirical high-dose cryoprecipitate for hemorrhage after traumatic injury: the CRYOSTAT-2 randomized clinical trial
Importance Critical bleeding is associated with a high mortality rate in patients with trauma.
Hemorrhage is exacerbated by a complex derangement of coagulation, including an acute …
Hemorrhage is exacerbated by a complex derangement of coagulation, including an acute …
Endothelial glycocalyx degradation in critical illness and injury
The endothelial glycocalyx is a gel-like layer on the luminal side of blood vessels that is
composed of glycosaminoglycans and the proteins that tether them to the plasma …
composed of glycosaminoglycans and the proteins that tether them to the plasma …
Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding
Treatment of bleeding disorders using transfusion of donor-derived platelets faces logistical
challenges due to their limited availability, high risk of contamination, and short (5 to 7 days) …
challenges due to their limited availability, high risk of contamination, and short (5 to 7 days) …
Prehospital lyophilized plasma transfusion for trauma-induced coagulopathy in patients at risk for hemorrhagic shock: a randomized clinical trial
D Jost, S Lemoine, F Lemoine, C Derkenne… - JAMA Network …, 2022 - jamanetwork.com
Importance Blood transfusion is a mainstay of therapy for trauma-induced coagulopathy, but
the optimal modalities for plasma transfusion in the prehospital setting remain to be defined …
the optimal modalities for plasma transfusion in the prehospital setting remain to be defined …
Hypothermia in trauma
MJ van Veelen, M Brodmann Maeder - International journal of …, 2021 - mdpi.com
Hypothermia in trauma patients is a common condition. It is aggravated by traumatic
hemorrhage, which leads to hypovolemic shock. This hypovolemic shock results in a lethal …
hemorrhage, which leads to hypovolemic shock. This hypovolemic shock results in a lethal …
[PDF][PDF] Management of trauma-induced coagulopathy with thrombelastography
Contemporary trauma care comprises advanced pre-hospital care, regionalized trauma
systems, damage control operative techniques, advanced critical care, rehabilitation with …
systems, damage control operative techniques, advanced critical care, rehabilitation with …
Relative hypercoagulopathy of the SARS-CoV-2 beta and delta variants when compared to the less severe omicron variants is related to TEG parameters, the extent of …
LM Grobbelaar, A Kruger, C Venter… - … in thrombosis and …, 2022 - thieme-connect.com
Earlier variants of SARS-CoV-2 have been associated with hypercoagulability and an
extensive formation of fibrin amyloid microclots, which are considered to contribute to the …
extensive formation of fibrin amyloid microclots, which are considered to contribute to the …