Melanogenesis is a complex process in which melanin is synthesized in melanocytes and
transported to keratinocytes, which involves multiple genes and signaling pathways …

Keratinocyte differentiation is an essential process for epidermal stratification and stratum
corneum formation. Keratinocytes proliferate in the basal layer of the epidermis and start …

Background Circular RNA (circRNA) has been implicated in various diseases; however, its
role in atopic dermatitis (AD) or psoriasis remains unclear. Objective We sought to determine …

Psoriasis is an incurable skin disease that develops in about two-thirds of patients before the
age of 40 and requires lifelong treatment; its pathological mechanisms have not been fully …

Oxidative stress plays an important pathogenetic role in many chronic inflammatory
diseases, including those of dermatological interest. In particular, regarding psoriasis …

Atopic dermatitis (AD), also known as atopic eczema, is a common but also complex chronic,
itchy skin condition with underlying inflammation of the skin. This skin ailment is prevalent …

Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease in which dry and
itchy skin may develop into skin lesions. AD has a strong genetic component, as children …

Previous work has shown increased expression of genes related to oxidative stress in
nonlesional atopic dermatitis (ADNL) skin. Although mitochondria are key regulators of ROS …

The understanding of the relationship between epigenetic alterations, their effects on gene
expression and the knowledge that these epigenetic alterations are reversible, have opened …

The skin is exposed to environmental challenges and contains skin-resident immune cells,
including mast cells (MCs) and CD8 T cells that act as sentinels for pathogens and …