Systems biology of angiogenesis signaling: Computational models and omics
Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …
cellular signal transduction, activation, proliferation, differentiation, as well as their …
Magnesium incorporation in fibrinogen scaffolds promotes macrophage polarization towards M2 phenotype
M Bessa-Gonçalves, C Ribeiro-Machado, M Costa… - Acta Biomaterialia, 2023 - Elsevier
The host inflammatory response to biomaterials conditions their capacity to promote tissue
repair, and macrophage polarization shift from M1 to M2 is determinant in this process …
repair, and macrophage polarization shift from M1 to M2 is determinant in this process …
Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease
AS Lagana, FM Salmeri, H Ban Frangež… - Gynecological …, 2020 - Taylor & Francis
Endometriosis is an estrogen-dependent disease defined by the presence and growth of
functional endometrial-like tissue, glands and stroma, outside the uterine cavity …
functional endometrial-like tissue, glands and stroma, outside the uterine cavity …
IL-1β and TNFα differentially influence NF-κB activity and FasL-induced apoptosis in primary murine hepatocytes during LPS-induced inflammation
J Rex, A Lutz, LE Faletti, U Albrecht, M Thomas… - Frontiers in …, 2019 - frontiersin.org
Macrophage-derived cytokines largely influence the behavior of hepatocytes during an
inflammatory response. We previously reported that both TNFα and IL-1β, which are …
inflammatory response. We previously reported that both TNFα and IL-1β, which are …
Virtual populations for quantitative systems pharmacology models
Quantitative systems pharmacology (QSP) places an emphasis on dynamic systems
modeling, incorporating considerations from systems biology modeling and …
modeling, incorporating considerations from systems biology modeling and …
Transcriptional and microenvironmental landscape of macrophage transition in cancer: A boolean analysis
U Avila-Ponce de León, A Vázquez-Jiménez… - Frontiers in …, 2021 - frontiersin.org
The balance between pro-and anti-inflammatory immune system responses is crucial to face
and counteract complex diseases such as cancer. Macrophages are an essential population …
and counteract complex diseases such as cancer. Macrophages are an essential population …
Multiplicity of mathematical modeling strategies to search for molecular and cellular insights into bacteria lung infection
Even today two bacterial lung infections, namely pneumonia and tuberculosis, are among
the 10 most frequent causes of death worldwide. These infections still lack effective …
the 10 most frequent causes of death worldwide. These infections still lack effective …
A data-driven computational model enables integrative and mechanistic characterization of dynamic macrophage polarization
Macrophages are highly plastic immune cells that dynamically integrate microenvironmental
signals to shape their own functional phenotypes, a process known as polarization. Here we …
signals to shape their own functional phenotypes, a process known as polarization. Here we …
Cancer mutationscape: revealing the link between modular restructuring and intervention efficacy among mutations
D Plaugher, D Murrugarra - NPJ Systems Biology and Applications, 2024 - nature.com
There is increasing evidence that biological systems are modular in both structure and
function. Complex biological signaling networks such as gene regulatory networks (GRNs) …
function. Complex biological signaling networks such as gene regulatory networks (GRNs) …
Computational approach to identifying universal macrophage biomarkers
Macrophages engulf and digest microbes, cellular debris, and various disease-associated
cells throughout the body. Understanding the dynamics of macrophage gene expression is …
cells throughout the body. Understanding the dynamics of macrophage gene expression is …