Background The assembly of a robust microtubule-based mitotic spindle is a prerequisite for
the accurate segregation of chromosomes to progeny. Spindle assembly relies on the …

The centrosome acts as the major microtubule-organizing center (MTOC) for cytoskeleton
maintenance in interphase and mitotic spindle assembly in vertebrate cells. It duplicates …

The nucleation of microtubules requires protein complexes containing γ-tubulin, which are
present in the cytoplasm and associate with the centrosome and with the mitotic spindle. We …

Centrosomes and primary cilia are usually considered as distinct organelles, although both
are assembled with the same evolutionary conserved, microtubule-based templates, the …

Centrosomes comprise a pair of centrioles surrounded by an amorphous pericentriolar
material (PCM). Here, we have performed a microscopy-based genome-wide RNA …

The unique ability of centrosomes to nucleate and organize microtubules makes them
unrivaled conductors of important interphase processes, such as intracellular payload traffic …

Centrosomes represent the major microtubule organizing centers (MTOCs) of animal
somatic cells and orchestrate bipolar spindle assembly during mitotic cell division. In meiotic …

Background The ways in which cells set the size of intracellular structures is an important but
largely unsolved problem [1]. Early embryonic divisions pose special problems in this …

The importance of oxygen for the survival of multicellular and aerobic organisms is well
established and documented. Over the years, increased knowledge of its use for …

The centriole organelle consists of microtubules (MTs) that exhibit a striking 9-fold radial
symmetry. Centrioles play fundamental roles across eukaryotes, notably in cell signaling …