Centrioles are microtubule-based structures crucial for forming flagella, cilia and
centrosomes. Through these roles, centrioles are critical notably for proper cell motility …

Centrosomes comprise a pair of centrioles surrounded by pericentriolar material (PCM). The
PCM expands dramatically as cells enter mitosis, but it is unclear how this occurs. In this …

Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the
cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a …

Despite decades of molecular analysis of the centrosome, an important microtubule-
organizing center (MTOC) of animal cells, the molecular basis of microtubule organization …

The centrosome comprises a pair of centrioles and associated pericentriolar material, and it
is the principal microtubule-organizing centre of most animal cells. Like the genetic material …

Centrosomes were first described by Edouard Van Beneden and named and linked to
chromosome segregation by Theodor Boveri around 1870. In the 1960–1980s, electron …

Centriole biogenesis and maintenance are crucial for cells to generate cilia and assemble
centrosomes that function as microtubule organizing centers (MTOCs). Centriole biogenesis …

Centrosomes must resist microtubule-mediated forces for mitotic chromosome segregation.
During mitotic exit, however, centrosomes are deformed and fractured by those same forces …

The cell cycle is an important cellular process whereby the cell attempts to replicate its
genome in an error-free manner. As such, mechanisms must exist for the cell cycle to …

Centrosomes consist of two centrioles embedded in pericentriolar material and function as
the main microtubule organising centres in dividing animal cells. They ensure proper …