Mitotic centrosomes assemble when centrioles recruit large amounts of pericentriolar
material (PCM) around themselves. In early C. elegans embryos, mitotic centrosome size …

Centrosomes are primary microtubule (MT)-organizing centers (MTOCs). During mitosis,
they dramatically increase their size and MT-nucleating activity and participate in spindle …

There is currently intense interest in the idea that many membraneless organelles might
assemble through phase separation of their constituent molecules into biomolecular' …

The centrosome is the best-understood microtubule-organizing center (MTOC) and is
essential in particular cell types and at specific stages during Drosophila development. The …

Centrioles function in the assembly of centrosomes and cilia. Structural and numerical
centrosome aberrations have long been implicated in cancer, and more recent genetic …

As one of four filament types, microtubules are a core component of the cytoskeleton and are
essential for cell function. Yet how microtubules are nucleated from their building blocks, the …

At the onset of mitosis, the centrosome undergoes maturation, which is characterized by a
drastic expansion of the pericentriolar material (PCM) and a robust increase in microtubule …

The pericentriolar material (PCM) that accumulates around the centriole expands during
mitosis and nucleates microtubules. Here, we show the cooperative roles of the centriole …

A striking but poorly explained feature of cell division is the ability to assemble and maintain
organelles not bounded by membranes, from freely diffusing components in the cytosol. This …

PHD1 belongs to the family of prolyl-4-hydroxylases (PHDs) that is responsible for
posttranslational modification of prolines on specific target proteins. Because PHD activity is …