Microtubule‐nucleation activity and structural integrity of the centrosome are critical for
various cellular functions. The γ‐tubulin ring complexes (γTuRCs) localizing to the …

Targeted protein degradation tools are becoming a new therapeutic modality, allowing small
molecule ligands to be reformulated as heterobifunctional molecules (PROteolysis Targeting …

The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division
and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited …

Centrosomes are composed of a centriole pair surrounded by an intricate proteinaceous
matrix referred to as pericentriolar material. Although the mechanisms underpinning the …

The sperm flagellum is essential for the transport of the genetic material toward the oocyte
and thus the transmission of the genetic information to the next generation. During the …

Throughout biology, specifying cellular events at the correct location and time is necessary
for ensuring proper function. The formation of robust microtubule organizing centers …

The centrosome, an organelle comprising centrioles and associated pericentriolar material,
is the major microtubule organizing center in animal cells. For the cell to form a bipolar …

Centrosomes nucleate and anchor microtubules and therefore play major roles in spindle
formation and chromosome segregation during mitosis. Duplication of the centrosome …

TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ
growth and increased tumor formation. TRIM37 depletion from tissue culture cells results in …

Hepatocellular carcinoma (HCC) responds poorly to standard chemotherapy or targeted
therapy; hence, exploration for novel therapeutic targets is urgently needed. CEP192 protein …