Human Cep57 is a coiled-coil scaffold at the pericentriolar matrix (PCM), controlling
centriole duplication and centrosome maturation for faithful cell division. Genetic truncation …

The Zika virus (ZIKV) is a mosquito-borne Flavivirus and can be transmitted through an
infected mosquito bite or through human-to-human interaction by sexual activity, blood …

Defects in meiotic spindle structure contribute to chromosome segregation errors leading to
genomic instability in oocytes and embryos upon fertilization. In this study, we analyzed the …

A functional centrosome is vital for the development and physiology of animals. Among
numerous regulatory mechanisms of the centrosome, ubiquitin‐mediated proteolysis is …

Polo kinase (PLK1 in mammals) is a master cell cycle regulator that is recruited to various
subcellular structures, often by its polo-box domain (PBD), which binds to phosphorylated S …

Pericentriolar material (PCM) present around a pair of centrioles functions as a platform for
various cellular processes, including microtubule (MT) assembly. While PCM is known to be …

CEP192 is a centrosome protein that plays a critical role in centrosome biogenesis and
function in mammals, Drosophila and C. elegans.-Moreover, CEP192-depleted cells arrest …

Accurate chromosome segregation is dependent on the formation and stability of the
microtubule spindle apparatus. Meiotic spindle assembly in oocytes differs from the process …

The major microtubule-organizing center (MTOC) in animal cells, the centrosome, comprises
a pair of centrioles surrounded by pericentriolar material (PCM), which nucleates and …

During cell division, microtubules organize a bipolar spindle to drive accurate chromosome
segregation to daughter cells. Microtubules are nucleated by the γ-TuRC, a γ-tubulin …