Centrosome duplication occurs under strict spatiotemporal regulation once per cell cycle,
and it begins with cartwheel assembly and daughter centriole biogenesis at the lateral sites …

Cep192 is a centrosomal protein that contributes to the formation and function of the mitotic
spindle in mammalian cells. Cep192's mitotic activities stem largely from its role in the …

Microtubules are organized by the centrosome, a dynamic organelle that exhibits changes in
both size and number during the cell cycle. Here we show that SZY-20, a putative RNA …

The Caenorhabditis elegans one-cell embryo is a powerful system in which to study
microtubule organization because this large cell assembles both meiotic and mitotic …

The nondegradable Mps1Δ12/13 protein drives centriole overproduction, suggesting that
Mps1 phosphorylates a subset of centrosomal proteins to drive the assembly of new …

The centrosomes in dividing cells follow a series of cyclical events of duplication and
separation, which are tightly linked to the cell cycle. Serine/threonine-protein kinase NEK7 …

Centrioles are the foundation of two organelles, centrosomes and cilia. Centriole numbers
and functions are tightly controlled, and mutations in centriole proteins are linked to a variety …

The centriole, or basal body, is the center of attachment between the sperm head and tail.
While the distal end of the centriole templates the cilia, the proximal end associates with the …

Centrosomes control cell motility, polarity and migration that is thought to be mediated by
their microtubule-organizing capacity. Here we demonstrate that WNT signalling drives a …

The correct segregation of DNA during cell division requires formation of a bipolar spindle,
organized at each pole by a centrosome. The regulation of centrosome duplication such that …