The predominantly animal-centric approach of chemical safety assessment has increasingly
come under pressure. Society is questioning overall performance, sustainability, continued …

Robust and efficient processes are needed to establish scientific confidence in new
approach methodologies (NAMs) if they are to be considered for regulatory applications …

Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

Abstract The EU Directive 2010/63/EU on the protection of animals used for scientific
purposes and other EU regulations, such as REACH and the Cosmetic Products Regulation …

Human in vitro models of brain neurophysiology are needed to investigate molecular and
cellular mechanisms associated with neurological disorders and neurotoxicity. We have …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

Background: Autism spectrum disorder (ASD) is a major public health concern caused by
complex genetic and environmental components. Mechanisms of gene–environment (G× E) …

Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human
exposome. However, DNT data from animal studies are available for only a small …

Currently, the identification of chemicals that have the potential to induce developmental
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …

Migration of neural progenitors in the complex tissue environment of the central nervous
system is not well understood. Progress in this area has the potential to drive breakthroughs …