[HTML][HTML] Tendon mechanical properties are enhanced via recombinant lysyl oxidase treatment

PK Nguyen, A Jana, C Huang, A Grafton… - … in Bioengineering and …, 2022 - frontiersin.org
Tendon mechanical properties are significantly compromised in adult tendon injuries,
tendon-related birth defects, and connective tissue disorders. Unfortunately, there currently …

Cyclic Stretching Triggers Cell Orientation and Extracellular Matrix Remodeling in a Periodontal Ligament 3D In Vitro Model

KH Chiu, M Karpat, J Hahn, KY Chang… - Advanced …, 2023 - Wiley Online Library
During orthodontic tooth movement (OTM), the periodontal ligament (PDL) plays a crucial
role in regulating the tissue remodeling process. To decipher the cellular and molecular …

Recombinant lysyl oxidase effects on embryonic tendon cell phenotype and behavior

PK Nguyen, K Hall, I Holt… - Journal of Orthopaedic …, 2023 - Wiley Online Library
Lysyl oxidase (LOX) plays an important role in the elaboration of tendon mechanical
properties during embryonic development by mediating enzymatic collagen crosslinking. We …

[HTML][HTML] The possible role of hypoxia in the affected tissue of relapsed clubfoot

T Novotny, A Eckhardt, M Doubkova, J Knitlova… - Scientific Reports, 2022 - nature.com
Our aim was to study the expression of hypoxia-related proteins as a possible regulatory
pathway in the contracted side tissue of relapsed clubfoot. We compared the expression of …

Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis

M Doubková, J Knitlová, D Vondrášek… - …, 2024 - ACS Publications
Fibrotic changes in pediatric clubfoot provide an opportunity to improve corrective therapy
and prevent relapses with targeted drugs. This study defines the parameters of clubfoot …

[HTML][HTML] Bovine Placentome-Derived Extracellular Matrix: A Sustainable 3D Scaffold for Cultivated Meat

C Bektas, K Lee, A Jackson, M Bhatia, Y Mao - Bioengineering, 2024 - mdpi.com
Cultivated meat, an advancement in cellular agriculture, holds promise in addressing
environmental, ethical, and health challenges associated with traditional meat production …

[HTML][HTML] Fibrosis and expression of extracellular matrix proteins in human interventricular septum in aortic valve stenosis and regurgitation

D Sedmera, A Kvasilova, A Eckhardt, P Kacer… - Histochemistry and Cell …, 2024 - Springer
Valvular heart disease leads to ventricular pressure and/or volume overload. Pressure
overload leads to fibrosis, which might regress with its resolution, but the limits and details of …

Screening for musculoskeletal system malformations and birth injuries in newborns: Results of a screening program in two hospitals in Shenzen, China

Z Xiong, Z Zhao, H Deng, X Qiu, W Li, X Chen… - Pediatric …, 2022 - mednexus.org
Importance: There are a variety of musculoskeletal malformations and injuries that can occur
in newborns. These can be a significant cause of perinatal death or a reason for miscarriage …

Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue

D Vondrášek, D Hadraba, J Přibyl… - Microscopy and …, 2023 - academic.oup.com
Talipes equinovarus congenitus (clubfoot) is frequently defined as a stiff, contracted
deformity, but few studies have described the tissue from the point of view of the extracellular …

Determining the Effects of Recombinant Lysyl Oxidase on Tendon Mechanical Properties and Cell Behaviors

PK Nguyen - 2023 - search.proquest.com
Tendon mechanical properties are significantly compromised in various scenarios including
adult tendon injuries, musculoskeletal birth defects, and connective tissue disorders …