Despite significant improvements in diagnosis, surgical techniques, and advancements in
general patient care, the majority of deaths from cancer are caused by the metastases …

The vascular endothelium is a dynamic cellular “organ” that controls passage of nutrients
into tissues, maintains the flow of blood, and regulates the trafficking of leukocytes. In …

Increased Myc gene copy number is observed in human prostate cancer. To define Myc's
functional role, we generated transgenic mice expressing human c-Myc in the mouse …

Efforts to selectively target and disrupt established tumor vasculature have largely failed to
date. We hypothesized that a vaccinia virus engineered to target cells with activation of the …

Multiple cellular pathways influence the growth and metastatic potential of tumors. This
creates heterogeneity, redundancy, and the potential for tumors to bypass signaling pathway …

Metastasis is a final stage of tumor progression. Breast and prostate cancer cells
preferentially metastasize to bone, wherein they cause incurable osteolytic and osteoblastic …

The epidermal growth factor receptor (EGFR) family comprehends four different tyrosine
kinases (EGFR, ErbB‐2, ErbB‐3, and ErbB‐4) that are activated following binding to …

The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, including
EGFR, HER2/erbB2, and HER3/erbB3, is an attractive target for antitumor strategies …

Purpose Bevacizumab (Avastin; Genentech, South San Francisco, CA) is a recombinant,
humanized anti-vascular endothelial growth factor monoclonal antibody. Erlotinib HCl …

Epithelial–mesenchymal transition (EMT) and cell transformation have been well-
documented in multiple cancer cell models and are believed to be one of the earliest events …