Over the past years, several lines of evidence support an antitumourigenic effect of
cannabinoids including Δ9‐tetrahydrocannabinol (Δ9‐THC), synthetic agonists …

The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to
describe the hypothetical factor responsible for myocyte hyperpolarisations not associated …

The study of P2X receptors has long been handicapped by a poverty of small-molecule tools
that serve as selective agonists and antagonists. There has been progress, particularly in …

Carbon monoxide (CO) and hydrogen sulfide (H 2 S) used to be thought of simply as lethal
and (for H 2 S) smelly gaseous molecules; now they are known to have important signaling …

Bivalent ligands are increasingly important therapeutic agents. Although the naturally
occurring antibodies are predominant, it is becoming more common to combine different …

BACKGROUND AND PURPOSE To evaluate the hypothesis that activation of
somatodendritic 5‐HT1A autoreceptors in the dorsal raphe nucleus (DRN) produces the anti …

Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along
with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on …

BACKGROUND AND PURPOSE In 2006, a life‐threatening 'cytokine storm', not predicted by
pre‐clinical safety testing, rapidly occurred in all six healthy volunteers during the phase I …

There has been a resurgence of interest in synthetic and plant‐derived flavonoids as
modulators of γ‐amino butyric acid‐A (GABAA) receptor function influencing inhibition …

BACKGROUND AND PURPOSE Cannabinoid receptor activation induces prostate
carcinoma cell (PCC) apoptosis, but cannabinoids other than Δ9‐tetrahydrocannabinol …