Anti‐platelet therapy: cyclo‐oxygenase inhibition and the use of aspirin with particular regard to dual anti‐platelet therapy

TD Warner, S Nylander… - British journal of clinical …, 2011 - Wiley Online Library
Aspirin and P2Y12 antagonists are commonly used anti‐platelet agents. Aspirin produces its
effects through inhibition of thromboxane A2 (TXA2) production, while P2Y12 antagonists …

Bleeding avoidance strategies: consensus and controversy

HL Dauerman, SV Rao, FS Resnic… - Journal of the American …, 2011 - jacc.org
Bleeding complications after coronary intervention are associated with prolonged
hospitalization, increased hospital costs, patient dissatisfaction, morbidity, and 1-year …

Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium

R Mehran, SV Rao, DL Bhatt, CM Gibson, A Caixeta… - Circulation, 2011 - Am Heart Assoc
Advances in antithrombotic therapy, along with an early invasive strategy, have reduced the
incidence of recurrent ischemic events and death in patients with acute coronary syndromes …

Heparin plus a glycoprotein IIb/IIIa inhibitor versus bivalirudin monotherapy and paclitaxel-eluting stents versus bare-metal stents in acute myocardial infarction …

GW Stone, B Witzenbichler, G Guagliumi, JZ Peruga… - The Lancet, 2011 - thelancet.com
Background Primary results of the HORIZONS-AMI trial have been previously reported. In
this final report, we aimed to assess 3-year outcomes. Methods HORIZONS-AMI was a …

Impact of bleeding on mortality after percutaneous coronary intervention: results from a patient-level pooled analysis of the REPLACE-2 (Randomized Evaluation of …

R Mehran, S Pocock, E Nikolsky, GD Dangas… - JACC: Cardiovascular …, 2011 - jacc.org
Objectives: This study sought to develop a risk score predictive of bleeding in patients
undergoing percutaneous coronary intervention (PCI) and to investigate the impact of …

Bivalirudin in patients undergoing primary angioplasty for acute myocardial infarction (HORIZONS-AMI): 1-year results of a randomised controlled trial

R Mehran, AJ Lansky, B Witzenbichler, G Guagliumi… - The Lancet, 2009 - thelancet.com
Summary Background In the HORIZONS-AMI trial, patients with acute ST-segment elevation
myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) who …

Bleeding-related deaths in relation to the duration of dual-antiplatelet therapy after coronary stenting

T Palmerini, L Bacchi Reggiani, D Della Riva… - Journal of the American …, 2017 - jacc.org
Background: Although some randomized controlled trials (RCTs) and meta-analyses have
suggested that prolonged dual-antiplatelet therapy (DAPT) may be associated with …

Significantly improved vascular complications among women undergoing percutaneous coronary intervention: a report from the Northern New England Percutaneous …

B Ahmed, WD Piper, D Malenka, P VerLee… - Circulation …, 2009 - Am Heart Assoc
Background—Women are at a higher risk for bleeding/vascular complications (VC) related
to cardiovascular procedures. Although the overall incidence of percutaneous coronary …

Impact of in-hospital major bleeding on late clinical outcomes after primary percutaneous coronary intervention in acute myocardial infarction: the HORIZONS-AMI …

JW Suh, R Mehran, BE Claessen, K Xu, U Baber… - Journal of the American …, 2011 - jacc.org
Objectives: We aimed to investigate the long-term prognosis of patients with in-hospital
major bleeding (IHMB). Background: The effect of IHMB on the long-term prognosis of …

Gender differences in coronary angiography, subsequent interventions, and outcomes among patients with acute coronary syndromes

GS Gudnadottir, K Andersen, IS Thrainsdottir… - American Heart …, 2017 - Elsevier
Background The objective was to investigate whether gender disparities are found in
referrals of patients with acute coronary syndromes to percutaneous coronary interventions …