Thyroid function is central in the control of physiological and pathophysiological processes.
Studies in animal models and human research have determined that thyroid hormones …

Neuropsychiatric dysfunction is common in overt hypothyroidism and will improve (perhaps
not completely resolve) with therapy. Deficits related to thyroid dysfunction are usually mild …

This chapter reviews the neurological phenotype of Down syndrome (DS) in early
development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as …

Context The standard of care for overt hypothyroidism is levothyroxine (LT4) at doses that
normalize serum TSH levels. Whether this approach universally restores thyroid hormone …

Background: A relationship between hypothyroidism and depression has been assumed for
many years; however, the true nature of this association has been difficult to define with …

The vital roles of thyroid hormone in multiple aspects of perinatal brain development have
been known for over a century. In the last decades, the molecular mechanisms underlying …

The endocrine system and particular endocrine organs, including the thyroid, undergo
important functional changes during aging. The prevalence of thyroid disorders increases …

The association of thyroid dysfunction with alterations in mood and cognition has been
recognised since some of the earliest descriptions of thyroid disease. Over the years …

Background The coexistence of subclinical hypothyroidism (SCH) and depression has been
intensively examined in the patients receiving thyroxine or antidepressant treatment. This …

Cognitive deficits are a core feature of serious mental illnesses such as major depression,
bipolar disorder and schizophrenia and are a common cause of functional disability …