Pesticides and human chronic diseases: evidences, mechanisms, and perspectives

S Mostafalou, M Abdollahi - Toxicology and applied pharmacology, 2013 - Elsevier
Along with the wide use of pesticides in the world, the concerns over their health impacts are
rapidly growing. There is a huge body of evidence on the relation between exposure to …

Mechanisms of cisplatin-induced ototoxicity and prevention

LP Rybak, CA Whitworth, D Mukherjea, V Ramkumar - Hearing research, 2007 - Elsevier
Cisplatin is a widely used chemotherapeutic agent to treat malignant disease. Unfortunately,
ototoxicity occurs in a large percentage of patients treated with higher dose regimens. In …

Environmental chemical exposures and human epigenetics

L Hou, X Zhang, D Wang… - International journal of …, 2012 - academic.oup.com
Every year more than 13 million deaths worldwide are due to environmental pollutants, and
approximately 24% of diseases are caused by environmental exposures that might be …

[PDF][PDF] Trichloroethene in drinking-water

World Health Organization - 2020 - apps.who.int
Access to safe drinking-water is essential to health, a basic human right and a component of
effective policy for health protection. A major World Health Organization (WHO) function to …

Human health effects of trichloroethylene: key findings and scientific issues

WA Chiu, J Jinot, CS Scott, SL Makris… - Environmental …, 2013 - ehp.niehs.nih.gov
Background: In support of the Integrated Risk Information System (IRIS), the US
Environmental Protection Agency (EPA) completed a toxicological review of …

Sucralose, a synthetic organochlorine sweetener: overview of biological issues

SS Schiffman, KI Rother - Journal of Toxicology and Environmental …, 2013 - Taylor & Francis
Sucralose is a synthetic organochlorine sweetener (OC) that is a common ingredient in the
world's food supply. Sucralose interacts with chemosensors in the alimentary tract that play a …

Epigenetic modifications of gene expression by lifestyle and environment

QA Abdul, BP Yu, HY Chung, HA Jung… - Archives of pharmacal …, 2017 - Springer
Epigenetics oftenly described as the heritable changes in gene expression independent of
changes in DNA sequence. Various environmental factors such as nutrition-dietary …

Cadmium and its epigenetic effects

B Wang, Y Li, C Shao, Y Tan… - Current medicinal …, 2012 - ingentaconnect.com
Cadmium (Cd) is a toxic, nonessential transition metal and contributes a health risk to
humans, including various cancers and cardiovascular diseases; however, underlying …

DNA hypomethylation in the origin and pathogenesis of human diseases

IP Pogribny, FA Beland - Cellular and Molecular Life Sciences, 2009 - Springer
The pathogenesis of any given human disease is a complex multifactorial process
characterized by many biologically significant and interdependent alterations. One of these …

Nongenotoxic carcinogenicity of chemicals: mechanisms of action and early recognition through a new set of structural alerts

R Benigni, C Bossa, O Tcheremenskaia - Chemical reviews, 2013 - ACS Publications
Cancer is the second leading cause of death in Western countries, just after circulatory
diseases. 1 Despite the considerable efforts and funds devoted to the research on cancer in …