Precision drug delivery to the central nervous system using engineered nanoparticles
Abstract Development of novel therapies for central nervous system (CNS) disorders has
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …
[HTML][HTML] Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics
Y Liu, Z Lin, Y Wang, L Chen, Y Wang, C Luo - Theranostics, 2024 - ncbi.nlm.nih.gov
Inflammatory dysregulation is intimately associated with the occurrence and progression of
many life-threatening diseases. Accurate detection and timely therapeutic intervention on …
many life-threatening diseases. Accurate detection and timely therapeutic intervention on …
The role of microglia in the pathogenesis of diabetic-associated cognitive dysfunction
W Xu, X Wang, X Hou, Y Yang, R Ma, R Lv… - Frontiers in …, 2024 - frontiersin.org
Diabetic-associated cognitive dysfunction (DACD) is a major central nervous system (CNS)
complication in patients with diabetes and is attracting increasing attention (1). Cognitive …
complication in patients with diabetes and is attracting increasing attention (1). Cognitive …
[HTML][HTML] Harnessing nanomedicine for modulating microglial states in the central nervous system disorders: Challenges and opportunities
H Li, M Guan, NN Zhang, Y Wang, T Liang… - Biomedicine & …, 2024 - Elsevier
Microglia are essential for maintaining homeostasis and responding to pathological events
in the central nervous system (CNS). Their dynamic and multidimensional states in different …
in the central nervous system (CNS). Their dynamic and multidimensional states in different …
Blood–Brain Barrier-Targeting Nanoparticles: Biomaterial Properties and Biomedical Applications in Translational Neuroscience
Overcoming the blood–brain barrier (BBB) remains a significant hurdle in effective drug
delivery to the brain. While the BBB serves as a crucial protective barrier, it poses …
delivery to the brain. While the BBB serves as a crucial protective barrier, it poses …
Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system
Short-interfering RNA (siRNA) has gained significant interest for treatment of neurological
diseases by providing the capacity to achieve sustained inhibition of nearly any gene target …
diseases by providing the capacity to achieve sustained inhibition of nearly any gene target …