Research criteria for the diagnosis of prodromal dementia with Lewy bodies

IG McKeith, TJ Ferman, AJ Thomas, F Blanc… - Neurology, 2020 - AAN Enterprises
The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive
impairment (MCI),(2) delirium-onset, and (3) psychiatric-onset presentations. The purpose of …

Olfactory dysfunction as an early biomarker in Parkinson's disease

ME Fullard, JF Morley, JE Duda - Neuroscience bulletin, 2017 - Springer
Olfactory dysfunction is common in Parkinson's disease (PD) and often predates the
diagnosis by years, reflecting early deposition of Lewy pathology, the histologic hallmark of …

[HTML][HTML] The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases

NL Rey, DW Wesson, P Brundin - Neurobiology of disease, 2018 - Elsevier
Olfactory deficits are present in numerous neurodegenerative disorders and are
accompanied by pathology in related brain regions. In several of these disorders, olfactory …

Dementia with Lewy bodies

I McKeith, J Mintzer, D Aarsland, D Burn… - The Lancet …, 2004 - thelancet.com
Dementia with Lewy bodies (DLB) is the second commonest cause of neurodegenerative
dementia in older people. It is part of the range of clinical presentations that share a neuritic …

Olfactory function in mild cognitive impairment and Alzheimer's disease: A meta‐analysis

HJ Jung, IS Shin, JE Lee - The Laryngoscope, 2019 - Wiley Online Library
Objective Olfactory function is altered in mild cognitive impairment (MCI) and Alzheimer's
disease (AD); therefore, it may serve as a useful tool for the early detection of MCI before its …

CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus

M Montero‐Odasso, F Pieruccini‐Faria… - … Research & Clinical …, 2020 - Wiley Online Library
Introduction Cognitive impairment is the hallmark of Alzheimer's disease (AD) and related
dementias. However, motor decline has been recently described as a prodromal state that …

Rapid eye movement sleep disruption and sleep fragmentation are associated with increased orexin-A cerebrospinal-fluid levels in mild cognitive impairment due to …

C Liguori, M Nuccetelli, F Izzi, G Sancesario… - Neurobiology of …, 2016 - Elsevier
The orexin system has been investigated in patients affected by mild cognitive impairment
(MCI) due to Alzheimer's disease (AD) by measuring orexin-A concentrations in the …

A quantitative meta-analysis of olfactory dysfunction in mild cognitive impairment

DR Roalf, MJ Moberg, BI Turetsky… - Journal of Neurology …, 2017 - jnnp.bmj.com
Background The connection between Alzheimer's disease (AD) and olfactory deficits is well
documented and further, alterations in olfactory functioning may signal declines in functions …

Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies

PC Donaghy, JP Taylor, JT O'Brien, N Barnett… - Psychological …, 2018 - cambridge.org
BackgroundThe accurate clinical characterisation of mild cognitive impairment (MCI) is
becoming increasingly important. The aim of this study was to compare the neuropsychiatric …

Insular atrophy at the prodromal stage of dementia with Lewy bodies: a VBM DARTEL study

D Roquet, V Noblet, P Anthony, N Philippi… - Scientific Reports, 2017 - nature.com
Diffuse atrophy including the insula was previously demonstrated in dementia with Lewy
bodies (DLB) patients but little is known about the prodromal stage of DLB (pro-DLB). In this …