In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

Xanthine oxidoreductase (XOR) is a complex molybdoflavoenzyme, present in milk and
many other tissues, which has been studied for over 100 years. While it is generally …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

Nitric oxide (NO•) is thought to protect against the damaging effects of myocardial ischemia–
reperfusion injury, whereas xanthine oxidoreductase (XOR) normally causes damage …

Background Dilated cardiomyopathy is characterized by an imbalance between left
ventricular performance and myocardial energy consumption. Experimental models suggest …

Allopurinol, an inhibitor of xanthine oxidase, increases myofilament calcium responsiveness
and blunts calcium cycling in isolated cardiac muscle. We sought to extend these …

Human xanthine oxidase was purified from breast milk. The dehydrogenase form of the
enzyme, which predominates in most mammalian tissues, catalyses the oxidation of NADH …

Conscious pigs underwent a sequence of 10 2-min coronary occlusions, each separated by
2 min of reperfusion, for three consecutive days (days 1, 2, and 3). On day 1, pigs received …

Cardiovascular disease (CVD) remains the leading cause of death in the United States.
There is evidence that shows a direct relationship between an elevated uric acid level and …