A topology-matching spike protein-capping tetrahedral DNA nanocrown for SARS-CoV-2 neutralization

J Chen, S Xu, Q Ye, H Chi, Y Li, M Wu, B Fan… - CCS …, 2023 - chinesechemsoc.org
The constantly mutating severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
poses great risk of efficacy loss to the present neutralizing therapeutics. Thus, it is urgently …

Biosensors based on bivalent and multivalent recognition by nucleic acid scaffolds

H Kim, H Choi, Y Heo, C Kim, M Kim, KT Kim - Applied Sciences, 2022 - mdpi.com
Several biological macromolecules adopt bivalent or multivalent interactions to perform
various cellular processes. In this regard, the development of molecular constructs …

Functional DNA structures for cytosensing

H Liu, Y Chen, H Ju - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Cells contain various biological molecules. Detection or imaging of these biomolecules in
situ or the cells themselves, which is defined as cytosensing, is an important issue in life …

Cell‐Friendly Isolation and pH‐Sensitive Controllable Release of Circulating Tumor Cells by Fe3O4@CaCO3 Nanoplatform

P Wang, J Xue, S Wu, Y Pei, L Xu… - Advanced Materials …, 2021 - Wiley Online Library
Circulating tumor cells (CTCs) have been recognized as significant research target for
cancer prognosis and metastasis mechanism. Efficient and all‐subpopulations‐covered …

The enhancement of enzyme cascading via tetrahedral DNA framework modification

H Zhao, M Li, S Lu, N Cao, X Zuo, S Wang, M Li - Analyst, 2023 - pubs.rsc.org
Enzyme clustering is widely used in many organisms to increase the catalytic efficiency of
cascade reactions. Inspired by nature, organizing enzymes within a cascade reaction also …

Cell Membrane-Anchored DNA Nanoinhibitor for Inhibition of Receptor Tyrosine Kinase Signaling Pathways via Steric Hindrance and Lysosome-Induced Protein …

J Tang, C Qi, X Bai, M Ji, Z Wang, Y Luo… - ACS Pharmacology & …, 2023 - ACS Publications
Receptor tyrosine kinase (RTK) plays a crucial role in cancer progression, and it has been
identified as a key drug target for cancer targeted therapy. Although traditional RTK-targeting …

A DNA-Programmed Cargo Distributing System in Living Cells

Y Wei, Y Feng, X Chen, W Ma, K Wang, Q Li… - CCS …, 2024 - chinesechemsoc.org
The functionalization of living cells, both internally and externally, transforming them into
micromachines with specified functions, holds significant potential in fields such as …

Recent advances in design strategies of aptamer‐based liquid biopsy

B Lin, JT Jiang, X Zhou - Journal of Polymer Science, 2024 - Wiley Online Library
Liquid biopsy represents a groundbreaking technology enabling the detection, analysis, and
monitoring of circulating targets in body fluids, such as blood, to acquire crucial molecular …

Hierarchical Fluid Interface Enables Spatiotemporal Regulation of Ligand Distribution to Increase Kinetics and Thermodynamics of Interfacial Binding Reaction

Q Niu, X Qu, S Li, X Shi, J Yang, J Feng… - Angewandte …, 2023 - Wiley Online Library
In nature, regulation of the spatiotemporal distribution of interfacial receptors and ligands
leads to optimum binding kinetics and thermodynamics of receptor–ligand binding reactions …

A colorimetric biosensor to track Trop-2 status of tumor cells for diagnosis of breast cancer

T Zeng, S Wu, Q Liang, H Shi, J Gong, N Duan… - Sensors and Actuators B …, 2023 - Elsevier
The emergence of antibody-drug conjugates (ADCs) targeting trophoblast cell-surface
antigen-2 (Trop-2) has reshaped the therapeutic landscape of advanced breast cancer …