A topology-matching spike protein-capping tetrahedral DNA nanocrown for SARS-CoV-2 neutralization
J Chen, S Xu, Q Ye, H Chi, Y Li, M Wu, B Fan… - CCS …, 2023 - chinesechemsoc.org
The constantly mutating severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
poses great risk of efficacy loss to the present neutralizing therapeutics. Thus, it is urgently …
poses great risk of efficacy loss to the present neutralizing therapeutics. Thus, it is urgently …
Biosensors based on bivalent and multivalent recognition by nucleic acid scaffolds
Several biological macromolecules adopt bivalent or multivalent interactions to perform
various cellular processes. In this regard, the development of molecular constructs …
various cellular processes. In this regard, the development of molecular constructs …
Functional DNA structures for cytosensing
Cells contain various biological molecules. Detection or imaging of these biomolecules in
situ or the cells themselves, which is defined as cytosensing, is an important issue in life …
situ or the cells themselves, which is defined as cytosensing, is an important issue in life …
Cell‐Friendly Isolation and pH‐Sensitive Controllable Release of Circulating Tumor Cells by Fe3O4@CaCO3 Nanoplatform
P Wang, J Xue, S Wu, Y Pei, L Xu… - Advanced Materials …, 2021 - Wiley Online Library
Circulating tumor cells (CTCs) have been recognized as significant research target for
cancer prognosis and metastasis mechanism. Efficient and all‐subpopulations‐covered …
cancer prognosis and metastasis mechanism. Efficient and all‐subpopulations‐covered …
The enhancement of enzyme cascading via tetrahedral DNA framework modification
Enzyme clustering is widely used in many organisms to increase the catalytic efficiency of
cascade reactions. Inspired by nature, organizing enzymes within a cascade reaction also …
cascade reactions. Inspired by nature, organizing enzymes within a cascade reaction also …
Cell Membrane-Anchored DNA Nanoinhibitor for Inhibition of Receptor Tyrosine Kinase Signaling Pathways via Steric Hindrance and Lysosome-Induced Protein …
J Tang, C Qi, X Bai, M Ji, Z Wang, Y Luo… - ACS Pharmacology & …, 2023 - ACS Publications
Receptor tyrosine kinase (RTK) plays a crucial role in cancer progression, and it has been
identified as a key drug target for cancer targeted therapy. Although traditional RTK-targeting …
identified as a key drug target for cancer targeted therapy. Although traditional RTK-targeting …
A DNA-Programmed Cargo Distributing System in Living Cells
Y Wei, Y Feng, X Chen, W Ma, K Wang, Q Li… - CCS …, 2024 - chinesechemsoc.org
The functionalization of living cells, both internally and externally, transforming them into
micromachines with specified functions, holds significant potential in fields such as …
micromachines with specified functions, holds significant potential in fields such as …
Recent advances in design strategies of aptamer‐based liquid biopsy
B Lin, JT Jiang, X Zhou - Journal of Polymer Science, 2024 - Wiley Online Library
Liquid biopsy represents a groundbreaking technology enabling the detection, analysis, and
monitoring of circulating targets in body fluids, such as blood, to acquire crucial molecular …
monitoring of circulating targets in body fluids, such as blood, to acquire crucial molecular …
Hierarchical Fluid Interface Enables Spatiotemporal Regulation of Ligand Distribution to Increase Kinetics and Thermodynamics of Interfacial Binding Reaction
Q Niu, X Qu, S Li, X Shi, J Yang, J Feng… - Angewandte …, 2023 - Wiley Online Library
In nature, regulation of the spatiotemporal distribution of interfacial receptors and ligands
leads to optimum binding kinetics and thermodynamics of receptor–ligand binding reactions …
leads to optimum binding kinetics and thermodynamics of receptor–ligand binding reactions …
A colorimetric biosensor to track Trop-2 status of tumor cells for diagnosis of breast cancer
T Zeng, S Wu, Q Liang, H Shi, J Gong, N Duan… - Sensors and Actuators B …, 2023 - Elsevier
The emergence of antibody-drug conjugates (ADCs) targeting trophoblast cell-surface
antigen-2 (Trop-2) has reshaped the therapeutic landscape of advanced breast cancer …
antigen-2 (Trop-2) has reshaped the therapeutic landscape of advanced breast cancer …