Despite many advances, our understanding of the involvement of prodynorphin systems in
the development of neuropathic pain is not fully understood. Recent studies suggest an …

Aims Epigenetic regulation is implicated in the neurogenesis of neuropathic pain. The
repressor element 1 (RE1) silencing transcription factor (REST) corepressor (CoREST) …

BACKGROUND & AIMS: The chronic, persistent pain associated with chronic pancreatitis
(CP) has many characteristics of neuropathic pain, initiated and maintained by the activation …

The 5-HT 7 receptor has recently gained much attention due to its involvement in multiple
physiological functions and diseases. The insufficient quality of the available molecular …

Neuropathic pain is a chronic condition that remains a major clinical problem owing to high
resistance to available therapy. Recent studies have indicated that chemokine signaling …

Minocycline is an inhibitor of matrix metalloproteinases (MMPs) and has been shown to
have analgesic effects. Whilst increased expression of MMPs is associated with neuropathic …

Paclitaxel‐induced painful peripheral neuropathy is a major dose‐limiting factor. Recently, it
has been reported that macrophages accumulated in the dorsal root ganglion of paclitaxel …

The aim of this study was to evaluate the analgesic as well as anti-inflammatory activities of
the new pyrrolo [3, 4-d] pyridazinone derivatives. Moreover, the present study attempted to …

Neuropathic pain treatment remains challenging due to ineffective therapy and resistance to
opioid analgesia. Mitogen-activated protein kinase kinase (MAPKK) have been identified as …

Spinal glial activation has been implicated in sustained morphine-mediated paradoxical
pain sensitization. Since activation of glial CB2 cannabinoid receptors attenuates spinal glial …