Liver cancer is an extraordinarily heterogeneous malignant disease among the tumors that
have so far been identified. Hepatocellular carcinoma (HCC) arises most frequently in the …

Tumor-associated macrophages (TAMs) represent an important cellular subset within the
glioblastoma (WHO grade IV) microenvironment and are a potential therapeutic target. TAMs …

Many different types of soft and solid tumors have now been sequenced, and meta-analyses
suggest that genomic variation across tumors scales with the stiffness of the tumors' tissues …

The effectiveness of the commonly used therapy is low for treating triple-negative breast
cancer (TNBC). Macrophages, accounting for up to 50% of the TNBC tumor mass, are …

Up to 40% of lung cancer patients develop brain metastasis, and the median survival of
these patients remains less than 6 months. Smoking is associated with lung cancer …

Tumor cells are thought to evade immune surveillance through interaction with immune
cells. Much recent attention has focused on the modification of immune responses as a …

Marrow-derived macrophages are highly phagocytic, but whether they can also traffic into
solid tumors and engulf cancer cells is questionable, given the well-known limitations of …

The Notch pathway plays critical roles in the development and functional modulation of
myeloid cells. Previous studies have demonstrated that Notch activation promotes M1 …

Signal regulatory protein-α (SIRPα) is a key member of the “do-not-eat-me” signaling
pathway, but its biological role and clinical relevance in B-cell NHL is relatively unknown …

In April 2013, a symposium was organized to highlight different aspects of differentiation and
activation of the monocyte‐macrophage lineage as analyzed on the flow cytometer …