Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by
nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in …

Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

IL-1β and TNF are potential targets in the management of neuropathic pain after injury.
However, the importance of the IL-1 and TNF systems for peripheral nerve regeneration and …

Lysophosphatidic acid (LPA) is a bioactive lipid with activity in the nervous system mediated
by G-protein-coupled receptors. Here, we examined the role of LPA signaling in the …

Background and Purpose Cannabinoids are a promising therapeutic avenue for chronic
pain. However, clinical trials often fail to report analgesic efficacy of cannabinoids. Inhibition …

Neuropathic pain is defined aspain initiated or caused by a primary lesion or dysfunction in
the nervous system'. 94 The spectrum of neuropathic pain covers a variety of disease states …

Neuropathic pain resulting from damage to or dysfunction of peripheral nerves is not well
understood and difficult to treat. Although CNS hyperexcitability is a critical component …