Microvascular barrier dysfunction is implicated in the initiation and progression of
inflammation, posttraumatic complications, sepsis, ischaemia–reperfusion injury …

Microvascular barrier dysfunction is a serious problem that occurs in many inflammatory
conditions, including sepsis, trauma, ischemia–reperfusion injury, cardiovascular disease …

A novel method was developed to measure the effective permeability of microvessels in
three-dimensional tumors. Two unique features characterized our approach:(i) Texas Red …

The biological fate of synthetic water‐soluble polymers administered to mice by injection at
different sites is described. After intraperitoneal (ip), subcutaneous (sc), and intramuscular …

Nitric oxide (NO) is an important regulator of blood flow, but its role in permeability is still
challenged. We tested in vivo the hypotheses that:(a) endothelial nitric oxide synthase …

The body distribution of pullulan and dextran, which are nonionic polysaccharides, was
studied. After intravenous injection of 125I-labeled polysaccharides with different molecular …

Key points• A specific therapy to treat capillary leakage in systemic inflammation and sepsis
is not available at present.• Recent studies demonstrated that reduced cAMP levels in …

We have developed a new method using fluorescence videomicroscopy to quantitate the
extravasation of intravenously injected materials. This method can measure the relative …

Microvascular hyperpermeability is a hallmark of inflammation. Many negative effects of
hyperpermeability are due to its persistence beyond what is required for preserving organ …

The adherens junction complex, composed mainly of vascular endothelial (VE)-cadherin, β-
catenin, p120, and γ-catenin, is the main element of the endothelial barrier in postcapillary …