The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

Leukemogenesis is a multistep process in which successive transformational events
enhance the ability of a clonal population arising from hematopoietic progenitor cells to …

Previous studies demonstrated that imatinib mesylate (IM) induces autophagy in chronic
myeloid leukemia (CML) and that this process is critical to cell survival upon therapy …

Aberrant expression of long noncoding RNAs (lncRNAs) is associated with various human
cancers. However, the role of lncRNAs in Bcr-Abl-mediated chronic myeloid leukemia (CML) …

Leukemia is one of the most common and aggressive adult cancers, as well as the most
prevalent childhood cancer. Leukemia is a cancer of the hematological system and can be …

Background The advanced phases of chronic myeloid leukemia (CML) are known to be
more resistant to therapy. This resistance has been associated with the overexpression of …

The introduction of ABL Tyrosine Kinase Inhibitors (TKIs) has significantly improved the
outcome of Chronic Myeloid Leukemia (CML) patients that, in large part, achieve satisfactory …

Background Imatinib mesylate (IM) induces clinical remission of chronic myeloid leukemia
(CML). The Abelson helper integration site 1 (AHI-1) oncoprotein interacts with BCR-ABL …

In more recent years, a significant increase in the number of available biological
experiments has taken place due to the widespread use of massive sequencing data …

The long noncoding RNA (lnc) maternally expressed 3 (MEG3) is downregulated in many
types of cancers. However, the relationship between lncRNA MEG3, microRNA-21 (miR-21) …