Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

Patients with moderate-to-severe asthma may now be treated using a variety of monoclonal
antibodies that target key inflammatory cytokines involved in disease pathogenesis. Existing …

The past 2 decades have seen a revolution in our approach to therapeutic
immunosuppression. We have moved from relying on broadly active traditional medications …

Asthma is a chronic and heterogenic respiratory tract disorder with a high global prevalence.
The underlying chronic inflammatory process and airway remodeling (AR) contribute to the …

Pericytes are a heterogeneous population of mesenchymal cells located on the abluminal
surface of microvessels, where they provide structural and biochemical support. Pericytes …

Immunoglobulin E (IgE)-associated allergy is the most common immune disorder. More than
30% of the population suffer from symptoms of allergy which are often severe, disabling, and …

Mast cells are tissue resident, innate immune cells with heterogenous phenotypes tuned by
cytokines and other microenvironmental stimuli. Playing a protective role in parasitic …

IgE-mediated type I hypersensitivity reactions have many reported beneficial functions in
immune defense against parasites, venoms, toxins, etc. However, they are best known for …

At present, there is no cure for asthma, and treatment typically involves therapies that
prevent or reduce asthma symptoms, without modifying the underlying disease. A “disease …

Mast cells are innate immune cells that intersect with the adaptive immunity and play a
crucial role in the initiation of allergic reactions and the host defense against certain …