Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Background: The dopaminergic system has been associated with the progression of
Alzheimer's disease. But previous studies found inconsistent results regarding the …

The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …

Dopamine (DA) is a neurotransmitter in the central nervous system as well as in peripheral
tissues. Emerging evidence however points to DA also as a key transmitter between the …

The traditional view on GPCRs held that they function as single monomeric units composed
of identical subunits. This notion was overturned by the discovery that GPCRs can form …

Adenosine is an endogenous purine nucleoside that acts in all living systems as a
homeostatic network regulator through many pathways, which are adenosine receptor (AR) …

Adenosine receptors are a family of GPCRs containing four subtypes (A1, A2A, A2B and A3
receptors), all of which bind the ubiquitous nucleoside adenosine. These receptors play an …

Introduction: Dopamine is a neurotransmitter widely distributed in both the periphery and the
central nervous system (CNS). Its physiological effects are mediated by five closely related G …

Major depressive disorder (MDD) is the foremost cause of global disability, being
responsible for enormous personal, societal, and economical costs. Importantly, existing …

Adenosine and dopamine interact antagonistically in living mammals. These interactions are
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …