[HTML][HTML] Molecular mechanisms of ferroptosis and relevance to cardiovascular disease

LH Xie, N Fefelova, SH Pamarthi, JK Gwathmey - Cells, 2022 - mdpi.com
Ferroptosis has recently been demonstrated to be a novel regulated non-apoptotic cell
death characterized by iron-dependence and the accumulation of lipid peroxidation that …

[HTML][HTML] The molecular mechanisms of ferroptosis and its role in cardiovascular disease

Y Zhang, L Xin, M Xiang, C Shang, Y Wang… - Biomedicine & …, 2022 - Elsevier
Ferroptosis is a programmed iron-dependent cell death characterized by accumulation of
lipid peroxides (LOOH) and redox disequilibrium. Ferroptosis shows unique characteristics …

Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2)/System xc-/glutathione …

S Xu, B Wu, B Zhong, L Lin, Y Ding, X Jin, Z Huang… - …, 2021 - Taylor & Francis
Ferroptosis is an important form of myocardial cell death in myocardial ischemia-reperfusion
injury (MIRI). Naringenin (NAR), as a flavonoid, has a significant advantage in improving …

Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis

Y Zhou, H Zhou, L Hua, C Hou, Q Jia, J Chen… - Free Radical Biology …, 2021 - Elsevier
Ferroptosis and pyroptosis have not been fully studied in atherosclerosis. We aimed to
investigate the expression of ferroptosis-related and pyroptosis-related proteins in human …

Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction

Z Xiao, B Kong, J Fang, T Qin, C Dai, W Shuai… - …, 2021 - Taylor & Francis
Cardiac dysfunction is a common complication of sepsis, and is attributed to severe
inflammatory responses. Ferroptosis is reported to be involved in sepsis-induced cardiac …

[HTML][HTML] Targeting ferroptosis against ischemia/reperfusion cardiac injury

J Lillo-Moya, C Rojas-Solé, D Muñoz-Salamanca… - Antioxidants, 2021 - mdpi.com
Ischemic heart disease is a leading cause of death worldwide. Primarily, ischemia causes
decreased oxygen supply, resulting in damage of the cardiac tissue. Naturally …

Ferroptosis and cardiovascular disease: role of free radical-induced lipid peroxidation

X Chen, X Li, X Xu, L Li, N Liang, L Zhang… - Free radical …, 2021 - Taylor & Francis
Cardiovascular disease (CVD), including heart attack, stroke, heart failure, arrhythmia, and
other congenital heart diseases remain the leading cause of morbidity and mortality …

Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression

X Sun, P Sun, D Zhen, X Xu, L Yang, D Fu… - Toxicology and Applied …, 2022 - Elsevier
Doxorubicin (Dox) is a high-efficiency agent for cancer therapy. However, it causes
cardiotoxicity which limits its clinical application. Despite more efforts has been made to …

[HTML][HTML] Emerging roles of ferroptosis in cardiovascular diseases

K Wang, XZ Chen, YH Wang, XL Cheng, Y Zhao… - Cell Death …, 2022 - nature.com
The mechanism of cardiovascular diseases (CVDs) is complex and threatens human health.
Cardiomyocyte death is an important participant in the pathophysiological basis of CVDs …

[HTML][HTML] Role of mitochondrial pathways in cell apoptosis during He-patic ischemia/reperfusion injury

S Zhang, S Rao, M Yang, C Ma, F Hong… - International journal of …, 2022 - mdpi.com
Hepatic ischemia-reperfusion injury is a major cause of post-operative hepatic dysfunction
and liver failure after transplantation. Mitochondrial pathways can be either beneficial or …