The spread of extended-spectrum β-lactamase (ESBL) genes in Enterobacteriaceae such as
Escherichia coli or Klebsiella spp is a major challenge to modern medical practice …

Drug bioavailability may vary greatly amongst individuals, affecting both efficacy and toxicity:
in humans, genetic variations account for a relevant proportion of such variability. In the last …

A mechanistic understanding of the relationship between the chemistry of drug Ag formation
and immune function is lacking. Thus, mass spectrometric methods were employed to detect …

Piperacillin-tazobactam is frequently used for empirical and targeted therapy of infections in
critically ill patients. Considerable pharmacokinetic (PK) variability is observed in critically ill …

Objectives: Augmented renal clearance (ARC) is a state of enhanced renal function
commonly observed in 30%–65% of critically ill patients despite normal serum creatinine …

While extended infusions of piperacillin-tazobactam (TZP) are increasingly used in practice,
the effect of infusion on the pharmacokinetic (PK) profile of TZP has not been widely …

Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …

Background Beta-lactam antimicrobial concentrations are frequently suboptimal in critically
ill patients. Population pharmacokinetic (PopPK) modeling is the golden standard to predict …

Since the discovery of penicillin, β-lactam antibiotics have commonly been used to treat
bacterial infections. Unfortunately, at the same time, pathogens can develop resistance to β …

Antibiotic resistance is a critical problem that results in a high morbidity and mortality rate.
The process of discovering new chemotherapy and antibiotics is challenging, expensive …