The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

The alveolar epithelium consists of (ATI) and type II (ATII) cells. ATI cells cover the majority of
the alveolar surface due to their thin, elongated shape and are largely responsible for barrier …

Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from impaired
regeneration of the alveolar epithelium after injury. During regeneration, type 2 alveolar …

Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious
agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery …

Many lung diseases result from a failure of efficient regeneration of damaged alveolar
epithelial cells (AECs) after lung injury. During regeneration, AEC2s proliferate to replace …

Mechanical ventilation applies physical stresses to the tissues of the lung and thus may give
rise to ventilator-induced lung injury (VILI), particular in patients with acute respiratory …

Senescence limits the characteristics and functionality of mesenchymal stem cells (MSCs),
thereby severely restricting their application in tissue engineering. Here, we investigated …

COVID-19 survivors often suffer from post-acute sequelae of SARS-CoV-2 infection (PASC).
Current evidence suggests dysregulated alveolar regeneration as a possible explanation for …

Lung function declines with advancing age. To improve our understanding of the structure-
function relationships leading to this decline, we investigated structural alterations in the …

Novel coronavirus disease 2019 (COVID-19) severity is highly variable, with pediatric
patients typically experiencing less severe infection than adults and especially the elderly …