Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation

J An, H Yang, Q Zhang, C Liu, J Zhao, L Zhang, B Chen - Life sciences, 2016 - Elsevier
Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone
mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling …

[HTML][HTML] Pathogenesis of osteoporosis: concepts, conflicts, and prospects

LG Raisz - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
Osteoporosis is a disorder in which loss of bone strength leads to fragility fractures. This
review examines the fundamental pathogenetic mechanisms underlying this disorder, which …

Genetics of osteoporosis

SH Ralston, AG Uitterlinden - Endocrine reviews, 2010 - academic.oup.com
Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …

[HTML][HTML] Role of transforming growth factor-β superfamily signaling pathways in human disease

KJ Gordon, GC Blobe - Biochimica et Biophysica Acta (BBA)-Molecular …, 2008 - Elsevier
Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and
essential regulators of cellular processes including proliferation, differentiation, migration …

Probiotics (Bifidobacterium longum) Increase Bone Mass Density and Upregulate Sparc and Bmp-2 Genes in Rats with Bone Loss Resulting from Ovariectomy

K Parvaneh, M Ebrahimi, MR Sabran… - BioMed research …, 2015 - Wiley Online Library
Probiotics are live microorganisms that exert beneficial effects on the host, when
administered in adequate amounts. Mostly, probiotics affect the gastrointestinal (GI) tract of …

Bone graft substitutes: current concepts and future expectations

DC Lobb, BR DeGeorge Jr, AB Chhabra - The Journal of hand surgery, 2019 - Elsevier
Owing to its osteoinductive and osteoconductive properties and the presence of osteogenic
cells, freshly harvested autologous bone graft is the gold standard for skeletal reconstruction …

[HTML][HTML] Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density

A Chesi, Y Wagley, ME Johnson, E Manduchi… - Nature …, 2019 - nature.com
Osteoporosis is a devastating disease with an essential genetic component. GWAS have
discovered genetic signals robustly associated with bone mineral density (BMD), but not the …

Genetic regulation of bone mass and susceptibility to osteoporosis

SH Ralston, B de Crombrugghe - Genes & development, 2006 - genesdev.cshlp.org
Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass and increased risk of fragility fractures. Twin and family studies have …

Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function

DC Glahn, PM Thompson, J Blangero - Human brain mapping, 2007 - Wiley Online Library
It is vitally important to identify the genetic determinants of complex brain‐related disorders
such as autism, dementia, mood disorders, and schizophrenia. However, the search for …

Melatonin promotes osteoblastic differentiation through the BMP/ERK/Wnt signaling pathways

KH Park, JW Kang, EM Lee, JS Kim… - Journal of pineal …, 2011 - Wiley Online Library
Although melatonin has a variety of biological actions such as antitumor, antiangiogenic,
and antioxidant activities, the osteogenic mechanism of melatonin still remains unclear …