Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation
Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone
mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling …
mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling …
[HTML][HTML] Pathogenesis of osteoporosis: concepts, conflicts, and prospects
LG Raisz - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
Osteoporosis is a disorder in which loss of bone strength leads to fragility fractures. This
review examines the fundamental pathogenetic mechanisms underlying this disorder, which …
review examines the fundamental pathogenetic mechanisms underlying this disorder, which …
Genetics of osteoporosis
SH Ralston, AG Uitterlinden - Endocrine reviews, 2010 - academic.oup.com
Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …
[HTML][HTML] Role of transforming growth factor-β superfamily signaling pathways in human disease
KJ Gordon, GC Blobe - Biochimica et Biophysica Acta (BBA)-Molecular …, 2008 - Elsevier
Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and
essential regulators of cellular processes including proliferation, differentiation, migration …
essential regulators of cellular processes including proliferation, differentiation, migration …
Probiotics (Bifidobacterium longum) Increase Bone Mass Density and Upregulate Sparc and Bmp-2 Genes in Rats with Bone Loss Resulting from Ovariectomy
Probiotics are live microorganisms that exert beneficial effects on the host, when
administered in adequate amounts. Mostly, probiotics affect the gastrointestinal (GI) tract of …
administered in adequate amounts. Mostly, probiotics affect the gastrointestinal (GI) tract of …
Bone graft substitutes: current concepts and future expectations
DC Lobb, BR DeGeorge Jr, AB Chhabra - The Journal of hand surgery, 2019 - Elsevier
Owing to its osteoinductive and osteoconductive properties and the presence of osteogenic
cells, freshly harvested autologous bone graft is the gold standard for skeletal reconstruction …
cells, freshly harvested autologous bone graft is the gold standard for skeletal reconstruction …
[HTML][HTML] Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density
Osteoporosis is a devastating disease with an essential genetic component. GWAS have
discovered genetic signals robustly associated with bone mineral density (BMD), but not the …
discovered genetic signals robustly associated with bone mineral density (BMD), but not the …
Genetic regulation of bone mass and susceptibility to osteoporosis
SH Ralston, B de Crombrugghe - Genes & development, 2006 - genesdev.cshlp.org
Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass and increased risk of fragility fractures. Twin and family studies have …
reduced bone mass and increased risk of fragility fractures. Twin and family studies have …
Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function
It is vitally important to identify the genetic determinants of complex brain‐related disorders
such as autism, dementia, mood disorders, and schizophrenia. However, the search for …
such as autism, dementia, mood disorders, and schizophrenia. However, the search for …
Melatonin promotes osteoblastic differentiation through the BMP/ERK/Wnt signaling pathways
KH Park, JW Kang, EM Lee, JS Kim… - Journal of pineal …, 2011 - Wiley Online Library
Although melatonin has a variety of biological actions such as antitumor, antiangiogenic,
and antioxidant activities, the osteogenic mechanism of melatonin still remains unclear …
and antioxidant activities, the osteogenic mechanism of melatonin still remains unclear …