Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

Frailty, a consequence of the interaction of the aging process and certain chronic diseases,
compromises functional outcomes in the elderly and substantially increases their risk for …

Abstract Background Oxidative stress (OxS) and mitochondrial dysfunction are implicated as
causative factors for aging. Older adults (OAs) have an increased prevalence of elevated …

Despite the wealth of epidemiological and experimental studies indicating the protective role
of regular physical activity/exercise training against the sequels of aging and cardiovascular …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …

Sarcopenia is a severe loss of muscle mass and functional decline during aging that can
lead to reduced quality of life, limited patient independence, and increased risk of falls. The …

Background Exercise is a major nonpharmacological treatment for hypertension, but its
underlying mechanisms are still not completely elucidated. Irisin, a polypeptide containing …

Key points The results of the present study establish the temporal pattern of age‐related
vascular dysfunction across the adult lifespan in sedentary mice consuming a non‐Western …

Vascular mitochondria constantly integrate signals from environment and respond
accordingly to match vascular function to metabolic requirements of the organ tissues, while …

Physical training is a potent therapeutic approach for improving mitochondrial health
through peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) …