The in vitro susceptibility testing interpretive criteria (STIC) for TZP against Enterobacterales
were recently updated by the Food and Drug Administration (FDA), Clinical & Laboratory …

Given the sparse antibiotic pipeline and the increasing prevalence of resistant organisms,
efforts should be made to optimise the pharmacodynamic exposure of currently available …

ABSTRACT A pharmacokinetic-pharmacodynamic (PKPD) model that characterizes the full
time course of in vitro time-kill curve experiments of antibacterial drugs was here evaluated …

Piperacillin-tazobactam (PTZ) is one of the most common antibiotics administered to
hospitalized patients. Its broad activity against gram-negative, gram-positive, and anaerobic …

Mechanisms coordinating pancreatic β cell metabolism with insulin secretion are essential
for glucose homeostasis. One key mechanism of β cell nutrient sensing uses the …

Introduction The aim of this study was to explore the impact of augmented creatinine
clearance and differing minimum inhibitory concentrations (MIC) on piperacillin …

Piperacillin-tazobactam is frequently used for empirical and targeted therapy of infections in
critically ill patients. Considerable pharmacokinetic (PK) variability is observed in critically ill …

Background Piperacillin levels after standard dosing have been shown frequently to be
subtherapeutic, especially when renal clearance was augmented. Here, we aimed to …

Infections and related sepsis are two of the most prevalent issues in the care of critically ill
patients, with mortality as high as 70%. Appropriate antibiotic selection, as well as adequate …

Optimization of antibiotic dosing is a treatment intervention that is likely to improve outcomes
in severe infections. The aim of this retrospective study was to describe the therapeutic …