The roles of matrix metalloproteinases and their inhibitors in human diseases

GA Cabral-Pacheco, I Garza-Veloz… - International journal of …, 2020 - mdpi.com
Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Modulation of immune‐inflammatory responses in abdominal aortic aneurysm: Emerging molecular targets

H Li, S Bai, Q Ao, X Wang, X Tian, X Li… - Journal of …, 2018 - Wiley Online Library
Abdominal aortic aneurysm (AAA), a deadly vascular disease in human, is a chronic
degenerative process of the abdominal aorta. In this process, inflammatory responses and …

METTL3 induces AAA development and progression by modulating N6-methyladenosine-dependent primary miR34a processing

L Zhong, X He, H Song, Y Sun, G Chen, X Si… - … Therapy-Nucleic Acids, 2020 - cell.com
Identifying effective drugs to delay the progression of aortic aneurysms is a formidable
challenge in vascular medicine. Methyltransferase-like 3 (METTL3) plays a key role in …

Circular RNAs in vascular functions and diseases

S Ding, Y Zhu, Y Liang, H Huang, Y Xu… - Circular RNAs: Biogenesis …, 2018 - Springer
Vascular disease is one of the top five causes of death and affects a variety of other
diseases, such as heart, nervous system, and metabolic disorders. Vascular dysfunction is a …

Epidemiological evidence between variants in matrix metalloproteinases-2,-7, and-9 and cancer risk

C Huang, S Xu, Z Luo, D Li, R Wang, T Wang - Frontiers in Oncology, 2022 - frontiersin.org
Background Matrix metalloproteinases (MMP s), a kind of proteases, have a critical function
in cancer occurrence, invasion, and migration. MMP gene variants (eg, MMP-2, MMP-7, and …

Epigenetic mechanisms underlying the benefits of flavonoids in cardiovascular health and diseases: are long non-coding RNAs rising stars?

Y Jiang, D Sun-Waterhouse, Y Chen… - Critical Reviews in Food …, 2022 - Taylor & Francis
Cardiovascular diseases (CVDs) rank as the first leading cause of death globally. High
dietary polyphenol (especially flavonoids) intake has strongly been associated with low …

Curcumin nicotinate suppresses abdominal aortic aneurysm pyroptosis via lncRNA PVT1/miR-26a/KLF4 axis through regulating the PI3K/AKT signaling pathway

JM Xiong, H Liu, J Chen, QQ Zou… - Toxicology …, 2021 - academic.oup.com
Abdominal aortic aneurysm (AAA) is a chronic dilated disease of the aorta that is
characterized by chronic inflammation. Curcumin (Cur) is previously showed to attenuate …

Nuclear paraspeckle assembly transcript 1 enhances hydrogen peroxide-induced human vascular smooth muscle cell injury by regulating miR-30d-5p/A disintegrin …

F Zhou, Z Zheng, Z Zha, T Xiong, Y Pan - Circulation Journal, 2022 - jstage.jst.go.jp
Background: Nuclear paraspeckle assembly transcript 1 (NEAT1) has been reported to be
involved in the progression of many cancers; however, the role and mechanisms underlying …

MicroRNA‐29a‐3p regulates abdominal aortic aneurysm development and progression via direct interaction with PTEN

Y Zhou, M Wang, J Zhang, P Xu… - Journal of Cellular …, 2020 - Wiley Online Library
Various research studies have been conducted in deducing the role of microRNAs
(miRNAs) in the pathogenesis and physiological processes of various systematic diseases …

Dexmedetomidine suppresses the development of abdominal aortic aneurysm by downregulating the mircoRNA‑21/PDCD 4 axis

Q Yu, Q Li, X Yang, Q Liu, J Deng… - International …, 2021 - spandidos-publications.com
Abdominal aortic aneurysm (AAA) is a pathological state with permanent dilation, which
indicates a fatal potential for aortic rupture. It has been reported that dexmedetomidine (Dex) …