Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Alteplase is currently the only approved thrombolytic agent for treatment of acute ischaemic
stroke, but interest is burgeoning in the development of new thrombolytic agents for systemic …

Ischemic stroke is the major type of cerebrovascular disease usually resulting in death or
disability among the aging population globally. Oxidative stress has been closely linked with …

The advent of highly successful reperfusion provides the opportunity to consider novel
approaches to cytoprotection as adjunctive therapies. Several therapeutic targets for …

Despite early thrombectomy, a sizeable fraction of acute stroke patients with large vessel
occlusion have poor outcome. The no-reflow phenomenon, ie impaired microvascular …

The ability to non-invasively visualize endogenous chromophores and exogenous probes
and sensors across the entire rodent brain with the high spatial and temporal resolution has …

Importance Treatment with remote ischemic perconditioning has been reported to reduce
brain infarction volume in animal models of stroke. Whether this neuroprotective effect was …

Stroke penumbra injury caused by excess glutamate is an important factor in determining
stroke outcome; however, several therapeutic approaches aiming to rescue the penumbra …

The social and public health burdens of ischemic stroke have been increasing worldwide. In
addition to focal brain damage, acute ischemic stroke (AIS) provokes systemic abnormalities …

Objective Patients with acute ischemic stroke harboring a large vessel occlusion who
present to primary stroke centers often require inter‐hospital transfer for thrombectomy. We …