Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

The discovery that heterozygous and homozygous mutations in the gene encoding
progranulin are causally linked to frontotemporal dementia and lysosomal storage disease …

Microglia maintain homeostasis in the brain, but whether aberrant microglial activation can
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …

The view of the lysosome as the terminal end of cellular catabolic pathways has been
challenged by recent studies showing a central role of this organelle in the control of cell …

Abstract GeneMANIA (http://www. genemania. org) is a flexible user-friendly web interface
for generating hypotheses about gene function, analyzing gene lists and prioritizing genes …

Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor
implicated in a multitude of processes ranging from regulation of inflammation to wound …

The application of RNA interference (RNAi) to mammalian cells has provided the means to
perform phenotypic screens to determine the functions of genes. Although RNAi has …

Complex network topology is characteristic of many biological systems, including anatomical
and functional brain networks (connectomes). Here, we first constructed a structural …

The discovery of potent inhibitors of the BRAF proto-oncogene has revolutionized therapy
for melanoma harboring mutations in BRAF, yet NRAS-mutant melanoma remains without …

Mutations in the progranulin (PGRN) gene have been linked to two distinct
neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal …