Hypromellose–A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery
E Mašková, K Kubová, BT Raimi-Abraham… - Journal of controlled …, 2020 - Elsevier
Hydroxypropylmethylcellulose (HPMC), also known as Hypromellose, is a traditional
pharmaceutical excipient widely exploited in oral sustained drug release matrix systems …
pharmaceutical excipient widely exploited in oral sustained drug release matrix systems …
Critical factors in the release of drugs from sustained release hydrophilic matrices
Hydrophilic matrix systems are one of the most interesting drug delivery systems, and they
are currently some of the most widely used to control the release rate of drugs. There are too …
are currently some of the most widely used to control the release rate of drugs. There are too …
Modulation of microenvironmental pH and crystallinity of ionizable telmisartan using alkalizers in solid dispersions for controlled release
The present work is an original evaluation of the microenvironmental pH (pHM) and
crystallinity of an ionizable drug in order to enhance its dissolution using alkalizers in …
crystallinity of an ionizable drug in order to enhance its dissolution using alkalizers in …
Correlating the behavior of polymers in solution as precipitation inhibitor to its amorphous stabilization ability in solid dispersions
Our major goals were to understand the mechanism of dipyridamole (DPD) precipitation
inhibition in the presence of polymers and to correlate the polymers-mediated precipitation …
inhibition in the presence of polymers and to correlate the polymers-mediated precipitation …
Controlled release systems containing solid dispersions: strategies and mechanisms
PHL Tran, TTD Tran, JB Park, BJ Lee - Pharmaceutical research, 2011 - Springer
In addition to a number of highly soluble drugs, most new chemical entities under
development are poorly water-soluble drugs generally characterized by an insufficient …
development are poorly water-soluble drugs generally characterized by an insufficient …
Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent solubility
C Taniguchi, Y Kawabata, K Wada… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Drug release and oral absorption of drugs with pH-dependent solubility are
influenced by the conditions in the gastrointestinal tract. In some cases, poor oral absorption …
influenced by the conditions in the gastrointestinal tract. In some cases, poor oral absorption …
Fabrication and evaluation of pH-modulated solid dispersion for telmisartan by spray-drying technique
The present study was undertaken to overcome the problems associated with solubility,
dissolution and oral bioavailability of a poorly water-soluble ionizable drug, telmisartan …
dissolution and oral bioavailability of a poorly water-soluble ionizable drug, telmisartan …
Extended-release oral drug delivery technologies: monolithic matrix systems
SB Tiwari, AR Rajabi-Siahboomi - Drug delivery systems, 2008 - Springer
Oral drug delivery is the largest and the oldest segment of the total drug delivery market. It is
the fastest growing and most preferred route for drug administration. Use of hydrophilic …
the fastest growing and most preferred route for drug administration. Use of hydrophilic …
Amorphous solid dispersions of weak bases with pH-dependent soluble polymers to overcome limited bioavailability due to gastric pH variability–an in-vitro approach
M Monschke, KG Wagner - International Journal of Pharmaceutics, 2019 - Elsevier
Several drugs are pH-dependent soluble weak bases with a poor solubility in the intestinal
pH range. Additionally a variable gastric pH, which is a common issue in the population …
pH range. Additionally a variable gastric pH, which is a common issue in the population …
Effect of pH modifiers on the solubility, dissolution rate, and stability of telmisartan solid dispersions produced by hot-melt extrusion technology
A Almotairy, M Almutairi, A Althobaiti, M Alyahya… - Journal of drug delivery …, 2021 - Elsevier
The aim of the current study was to investigate the dual effect of an amorphous solid
dispersion generated by hot melt extrusion and the addition of pH modifiers on the solubility …
dispersion generated by hot melt extrusion and the addition of pH modifiers on the solubility …