All organisms possess molecular mechanisms that govern DNA repair and associated DNA
damage response (DDR) processes. Owing to their relevance to human disease, most …

The neuronal genome is particularly sensitive to loss or attenuation of DNA repair, and many
neurological diseases ensue when DNA repair is impaired. It is well-established that the …

The extensive length, compaction, and interwound nature of DNA, together with its
controlled and restricted movement in eukaryotic cells, create a number of topological issues …

Genome damage and transcription are intimately linked. Tens to hundreds of thousands of
DNA lesions arise in each cell each day, many of which can directly or indirectly impede …

Non-homologous end joining is the major double-strand break repair (DSBR) pathway in
mammals. DNA-PK is the hub and organizer of multiple steps in non-homologous end …

Abstract Poly (ADP)-ribosylation (PARylation) regulates chromatin structure and recruits
DNA repair proteins. Using single-molecule fluorescence microscopy to track topoisomerase …

Prostate cancer exerts a greater toll on African American men than on White men of
European descent (hereafter referred to as European American men): the disparity in …

Type II topoisomerases transiently cleave duplex DNA as part of a strand passage
mechanism that helps control chromosomal organization and superstructure. Aberrant DNA …

Topoisomerases play crucial roles in DNA metabolism that include replication, transcription,
recombination, and chromatin structure by manipulating DNA structures arising in double …

Topoisomerases regulate DNA topology, organization of the intracellular DNA, the
transmission of genetic materials, and gene expressions. Other than the nuclear genome …