Growing data show the association of metabolic syndrome (MetS) or its components with
cancer development and cancer-related mortality. It is suggested that in MetS and cancer …

Cancer cells acquire cell-autonomous capacities to undergo limitless proliferation and
survival through the activation of oncogenes and inactivation of tumor suppressor genes …

Growing evidence indicates that inflammation is a contributing factor leading to cancer
development. However, pathways involved in this progression are not well understood. To …

Histone deacetylases (HDACs) are a class of enzymes that remove acetyl from the ε-N-
acetyl lysine of histones, allowing histones to wrap DNA more tightly. HDACs play an …

Chemotherapy with a single chemotherapeutic agent or a combined chemotherapeutic
regimen is the clinically standardized treatment for almost all human cancers. Upregulated …

Background Cancer is a major burden of disease worldwide and increasing evidence shows
that inflammation contributes to cancer development and progression. Eicosanoids are …

Recently, molecular hybridization paradigm became an interesting and smart way to defeat
the multifaceted cancer disease by a single molecular entity that acts via several …

Cellular signaling pathways involved in the maintenance of the equilibrium between cell
proliferation and apoptosis have emerged as rational targets that can be exploited in the …

Conclusion. Our results show that average and poor oral hygiene and inadequate dental
status are independent risk factors for oral and oropharyngeal squamous cell carcinoma …

Squamous cell carcinoma (SCC) is an epithelial malignancy involving many anatomical
sites and is the most common cancer capable of metastatic spread. Development of early …