Multilayered and versatile inhibition of cellular antiviral factors by HIV and SIV accessory proteins
D Sauter, F Kirchhoff - Cytokine & growth factor reviews, 2018 - Elsevier
HIV-1, the main causative agent of AIDS, and related primate lentiviruses show a striking
ability to efficiently replicate throughout the lifetime of an infected host. In addition to their …
ability to efficiently replicate throughout the lifetime of an infected host. In addition to their …
Multifaceted roles of TIM-family proteins in virus–host interactions
JP Evans, SL Liu - Trends in microbiology, 2020 - cell.com
To enhance infection, enveloped viruses exploit adhesion molecules expressed on the
surface of host cells. Specifically, phosphatidylserine (PS) receptors–including members of …
surface of host cells. Specifically, phosphatidylserine (PS) receptors–including members of …
Vpu-mediated counteraction of tetherin is a major determinant of HIV-1 interferon resistance
Human immunodeficiency virus type 1 (HIV-1) groups M, N, O, and P are the result of
independent zoonotic transmissions of simian immunodeficiency viruses (SIVs) infecting …
independent zoonotic transmissions of simian immunodeficiency viruses (SIVs) infecting …
Parallel molecular evolution and adaptation in viruses
Parallel molecular evolution is the independent evolution of the same genotype or
phenotype from distinct ancestors. The simple genomes and rapid evolution of many viruses …
phenotype from distinct ancestors. The simple genomes and rapid evolution of many viruses …
Post-translational modification-based regulation of HIV replication
L Chen, OT Keppler, C Schölz - Frontiers in Microbiology, 2018 - frontiersin.org
Human immunodeficiency virus (HIV) relies heavily on the host cellular machinery for
production of viral progeny. To exploit cellular proteins for replication and to overcome host …
production of viral progeny. To exploit cellular proteins for replication and to overcome host …
HIV-1 Nefs are cargo-sensitive AP-1 trimerization switches in tetherin downregulation
KL Morris, CZ Buffalo, CM Stürzel, E Heusinger… - Cell, 2018 - cell.com
The HIV accessory protein Nef counteracts immune defenses by subverting coated vesicle
pathways. The 3.7 Å cryo-EM structure of a closed trimer of the clathrin adaptor AP-1, the …
pathways. The 3.7 Å cryo-EM structure of a closed trimer of the clathrin adaptor AP-1, the …
Primary HIV-1 strains use Nef to downmodulate HLA-E surface expression
T van Stigt Thans, JI Akko, A Niehrs… - Journal of …, 2019 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) has evolved elaborate ways to evade
immune cell recognition, including downregulation of classical HLA class I (HLA-I) from the …
immune cell recognition, including downregulation of classical HLA class I (HLA-I) from the …
Stably expressed APOBEC3H forms a barrier for cross-species transmission of simian immunodeficiency virus of chimpanzee to humans
APOBEC3s (A3s) are potent restriction factors of human immunodeficiency virus type
1/simian immunodeficiency viruses (HIV-1/SIV), and can repress cross-species …
1/simian immunodeficiency viruses (HIV-1/SIV), and can repress cross-species …
TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins
The T cell Ig and mucin domain (TIM) proteins inhibit release of HIV-1 and other enveloped
viruses by interacting with cell-and virion-associated phosphatidylserine (PS). Here, we …
viruses by interacting with cell-and virion-associated phosphatidylserine (PS). Here, we …
HIV-1 Nef hijacks clathrin coats by stabilizing AP-1: Arf1 polygons
INTRODUCTION Clathrin-coated vesicles mediate endocytosis and sorting from the trans-
Golgi network (TGN) and endosomes to lysosomes. Adaptor protein (AP) complexes such as …
Golgi network (TGN) and endosomes to lysosomes. Adaptor protein (AP) complexes such as …