This Account provides an overview and examples of function-oriented synthesis (FOS) and
its increasingly important role in producing therapeutic leads that can be made in a step …

The subject of this review is the biodiversity of marine sponges and associated microbes
which have been reported to produce therapeutically important compounds, along with the …

Protein kinase C (PKC) comprises a family of serine/threonine kinases that are involved in
the transduction of signals for cell proliferation, differentiation, apoptosis and angiogenesis …

Multidrug resistance and disease relapse is a challenging clinical problem in the treatment
of breast cancer. In this study, we investigated the hyaluronan (HA)-induced interaction …

Signal transduction in cancer cells is a sophisticated process that involves receptor tyrosine
kinases (RTKs) that eventually trigger multiple cytoplasmic kinases, which are often …

The naturally occurring 1-O-alkyl-sn-glycerols and their methoxylated congeners, 1-O-(2′-
methoxyalkyl)-sn-glycerols, are biologically active compounds, ubiquitously found in nature …

Growth factor signals are propagated from the cell surface, through the action of
transmembrane receptors, to intracellular effectors that control critical functions in human …

The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that signals in
response to extracellular calcium and regulates parathyroid hormone secretion. The CaR is …

Natural products have been an integral part of sustaining civilizations because of their
medicinal properties. Past discoveries of bioactive natural products have relied on …

Protein kinases C (PKCs) are a family of serine/threonine kinases which are involved in
tumor formation and progression. Although PKC over-expression has been shown to …