Cytotoxic T cells are important effectors of anti-tumor immunity. While tumor killing is
ascribed to CD8+ T cell function, pre-clinical and clinical studies have identified intra …

Within the past decade, the field of immunotherapy has revolutionized the treatment of many
cancers with the development and regulatory approval of various immune-checkpoint …

The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …

Purpose: The purpose of this study was to evaluate antigen experienced T cells in
peripheral blood lymphocytes (PBL) for responses to p53 neoantigens. Experimental …

Bacillus Calmette–Guérin (BCG) immunotherapy for bladder cancer is the only bacterial
cancer therapy approved for clinical use. Although presumed to induce T cell-mediated …

Simple Summary Bacillus Calmette–Guérin (BCG), a live attenuated strain of Mycobacterium
bovis, is the most successful microbial immunotherapy of cancer in current use. Intravesical …

There is a great need to improve the outlook for people facing urinary bladder cancer,
especially for patients with invasive urothelial carcinoma (InvUC) which is lethal in 50% of …

Major histocompatibility complex (MHC) class II molecules play a pivotal role in antigen
presentation and CD4+ T cell response. Accurate prediction of the immunogenicity of MHC …

Adoptive cell transfer (ACT) is a promising approach to cancer immunotherapy, but its
efficiency fundamentally depends on the extent of tumor-specific T cell enrichment within the …

Bladder cancer (BC) constitutes one of the most diagnosed types of cancer worldwide.
Advancements in and new methodologies for DNA sequencing, leading to high-throughput …