Recent meta-analyses report a 70% increase in fracture risk in selective serotonin reuptake
inhibitor (SSRI) users compared to non-users; however, included studies were observational …

Hypothesis/Objectives Altered serotonin (5‐hydroxytryptamine, 5 HT) signaling is postulated
in development and progression of canine myxomatous mitral valve disease (MMVD). Little …

ABSTRACT Plasma serotonin (5-hydroxytryptamine, 5-HT) homeostasis is maintained
through the combined processes of uptake (via the 5-HT transporter SERT, and others) …

Numerous vasoactive agents play an important physiological role in regulating vascular
tone, reactivity and structure. In pathological conditions, alterations in the regulation of …

Depression resulted as an important factor associated with the myocardial infarction (MI)
prognosis. Patients with MI also have a higher risk for developing depression. Although the …

In the conventional model of serotonin neurotransmission, serotonin released by neurons in
the midbrain raphe nuclei exerts its actions on forebrain neurons by interacting with a large …

Background Depression has been recognized as an independent risk factor of coronary
heart disease (CHD). Moreover, there is interrelationship of both depression and CHD …

Gestational diabetes (GDM) is characterized by a glucose tolerance disorder. This may first
appear during pregnancy or pre-exist before conception as a form of prediabetes, but there …

The serotonin transporter is implicated in the uptake of the vasoconstrictor serotonin from the
circulation into the platelets, where 95% of all blood serotonin is stored and released in …

Although past studies demonstrate that altered serotonin (5-HT) signaling is present in
adults with idiopathic pulmonary arterial hypertension, whether serotonin contributes to the …