Pt-based drugs: the spotlight will be on proteins

O Pinato, C Musetti, C Sissi - Metallomics, 2014 - academic.oup.com
Platinum-complexes represent some of the most successful groups of clinically used
anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts …

Zinc‐Catalyzed Amide Cleavage and Esterification of β‐Hydroxyethylamides

Y Kita, Y Nishii, T Higuchi, K Mashima - Angewandte Chemie, 2012 - infona.pl
Schneidewerkzeug: Zn (OTf) 2 ist ein effizienter Katalysator für die selektive Spaltung von
Amiden mit β‐Hydroxyethylgruppe am Stickstoffatom. Der Mechanismus umfasst eine N, O …

Target-selective delivery and activation of platinum-based anticancer agents

S Ding, U Bierbach - Future Medicinal Chemistry, 2015 - Future Science
Platinum-based agents continue to be a mainstay as components of many standard
chemotherapy regimens. To improve the tolerability and efficacy of these important oncology …

Selective hydrolysis of oxidized insulin chain B by a Zr (IV)-substituted Wells–Dawson polyoxometalate

A Sap, G Absillis, TN Parac-Vogt - Dalton Transactions, 2015 - pubs.rsc.org
We report for the first time on the selective hydrolysis of a polypeptide system by a metal-
substituted polyoxometalate (POM). Oxidized insulin chain B, a 30 amino acid polypeptide …

Esterification of Tertiary Amides by Alcohols Through C−N Bond Cleavage over CeO2

T Toyao, M Nurnobi Rashed, Y Morita… - …, 2019 - Wiley Online Library
CeO2 has been found to promote ester forming alcoholysis reactions of tertiary amides. The
present catalytic system is operationally simple, recyclable, and it does not require additives …

Hydrolysis of chemically distinct sites of human serum albumin by polyoxometalate: A hybrid QM/MM (ONIOM) study

VM Jayasinghe‐Arachchige, Q Hu… - Journal of …, 2019 - Wiley Online Library
In this study, mechanisms of hydrolysis of all four chemically diverse cleavage sites of
human serum albumin (HSA) by [Zr (OH)(PW11O39)] 4−(ZrK) have been investigated using …

Peptide hydrolysis by metal-cyclen complexes and their analogues: insights from theoretical studies

T Zhang, X Zhu, R Prabhakar - Organometallics, 2014 - ACS Publications
In the present DFT study, mechanisms of peptide hydrolysis by Co (III)-and Cu (II)-containing
complexes of 1, 4, 7, 10-tetraazacyclododecane (cyclen), 1-Co and 1-Cu, respectively, and 1 …

Combined theoretical and experimental study on alcoholysis of amides on CeO2 surface: A catalytic interplay between Lewis acid and base sites

T Kamachi, SMAH Siddiki, Y Morita, MN Rashed, K Kon… - Catalysis Today, 2018 - Elsevier
Alcoholysis of amides on the CeO 2 surface is investigated from density functional theory
(DFT) computations, in situ FT-IR spectroscopy, and catalytic studies. The …

Effects of ligand environment in Zr (IV) assisted peptide hydrolysis

T Zhang, G Sharma, TJ Paul, Z Hoffmann… - Journal of chemical …, 2017 - ACS Publications
In this DFT study, activities of 11 different N2O4, N2O3, and NO2 core containing Zr (IV)
complexes, 4, 13-diaza-18-crown-6 (I′ N2O4), 1, 4, 10-trioxa-7, 13-diazacyclopentadecane …

Mechanistic Insights into Metal (Pd2+, Co2+, and Zn2+)−β-Cyclodextrin Catalyzed Peptide Hydrolysis: A QM/MM Approach

T Zhang, X Zhu, R Prabhakar - The Journal of Physical Chemistry …, 2014 - ACS Publications
In this study, mechanistic insights into the hydrolysis of an extremely stable tertiary peptide
bond (Ser–Pro) in the Ser-Pro-Phe sequence by an artificial enzyme, metal (Pd2+, Co2+, or …