Structure and mechanism-guided design of dual serine/metallo-carbapenemase inhibitors

C Chen, P Oelschlaeger, D Wang, H Xu… - Journal of Medicinal …, 2022 - ACS Publications
Serine/metallo-carbapenemase-coproducing pathogens, often referred to as “superbugs”,
are a significant clinical problem. They hydrolyze nearly all available β-lactam antibiotics …

[HTML][HTML] Promising applications of D-amino acids in periprosthetic joint infection

M Caldwell, M Hughes, F Wei, C Ngo, R Pascua… - Bone Research, 2023 - nature.com
Due to the rise in our aging population, a disproportionate demand for total joint arthroplasty
(TJA) in the elderly is forecast. Periprosthetic joint infection (PJI) represents one of the most …

[HTML][HTML] Acinetobacter baumannii IC2 and IC5 Isolates with Co-Existing blaOXA-143-like and blaOXA-72 and Exhibiting Strong Biofilm Formation in a Mexican …

J Moreno-Manjón, S Castillo-Ramírez, KA Jolley… - Microorganisms, 2023 - mdpi.com
Acinetobacter baumannii is an opportunistic pathogen responsible for healthcare-
associated infections (HAIs) and outbreaks. Antimicrobial resistance mechanisms and …

Aptamer-based DNA-catalyzed amplification strategy for sensitive fluorescence resonance energy transfer detection of Acinetobacter baumannii

J Xie, H Jiang, Y Zhao, M Zhong, X Jin, Z Zhu, B Li… - Talanta, 2023 - Elsevier
Acinetobacter baumannii (A. baumannii) is a common pathogen that causes hospital-
acquired infections and is resistant to a wide variety of antibiotics. Consequently, the rapid …

[HTML][HTML] Acinetobacter Non-baumannii Species: Occurrence in Infections in Hospitalized Patients, Identification, and Antibiotic Resistance

E Sheck, A Romanov, V Shapovalova, E Shaidullina… - Antibiotics, 2023 - mdpi.com
Background: Acinetobacter species other than A. baumannii are becoming increasingly
more important as opportunistic pathogens for humans. The primary aim of this study was to …

[HTML][HTML] Whole-Genome Sequencing (WGS) of Carbapenem-Resistant K. pneumoniae Isolated in Long-Term Care Facilities in the Northern Italian Region

A Piccirilli, S Cherubini, AM Azzini, E Tacconelli… - Microorganisms, 2021 - mdpi.com
K. pneumoniae (KPN) is one of the widest spread bacteria in which combined resistance to
several antimicrobial groups is frequent. The most common β-lactamases found in K …

[HTML][HTML] Acinetobacter baumannii, a Multidrug-Resistant Opportunistic Pathogen in New Habitats: A Systematic Review

OE Ahuatzin-Flores, E Torres, E Chávez-Bravo - Microorganisms, 2024 - mdpi.com
In recent years, humanity has begun to face a growing challenge posed by a rise in the
prevalence of antibiotic-resistant bacteria. This has resulted in an alarming surge in fatalities …

Extensively drug-resistant Acinetobacter baumannii nosocomial pneumonia successfully treated with a novel antibiotic combination

N Zaidan, JP Hornak, D Reynoso - Antimicrobial agents and …, 2021 - Am Soc Microbiol
Extremely drug-resistant (XDR) Acinetobacter baumannii causes challenging nosocomial
infections. We report the case of a patient with XDR A. baumannii pneumonia and septic …

[HTML][HTML] Infection and burn injury

EJ Kelly, MA Oliver, BC Carney, JW Shupp - European Burn Journal, 2022 - mdpi.com
Burn injury is debilitating and among one of the most frequently occurring traumas. Critical
care improvements have allowed for increasingly positive outcomes. However, infection …

[HTML][HTML] Current state of knowledge regarding WHO critical priority pathogens: Mechanisms of resistance and proposed solutions through candidates such as …

B Badescu, V Buda, M Romanescu, A Lombrea… - Plants, 2022 - mdpi.com
The rise of multidrug-resistant (MDR) pathogens has become a global health threat and an
economic burden in providing adequate and effective treatment for many infections. This …