[PDF][PDF] NLRP3 炎性小体在慢性心力衰竭中的作用与机制

王敢, 钟江华 - 临床心血管病杂志, 2023 - en.whuhzzs.com
慢性心力衰竭(chronicheartfailure, CHF) 是各类心血管疾病的终末期阶段. CHF
的治疗方案近年虽不断完善, 但仍有较高的死亡率与住院率, 给患者及家庭带来了巨大的医疗 …

IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction

J Huang, W Kuang, Z Zhou - Inflammopharmacology, 2024 - Springer
Acute myocardial infarction is an important cardiovascular disease worldwide. Although the
mortality rate of myocardial infarction (MI) has improved dramatically in recent years due to …

Clinical and pharmacological implications of time to treatment with interleukin-1 blockade in ST-segment elevation myocardial infarction

MG Del Buono, JI Damonte, F Moroni… - … of Pharmacology and …, 2023 - ASPET
Interleukin-1 (IL-1) blockade with anakinra given within 12 hours from reperfusion has been
shown to reduce the inflammatory response as well as prevent heart failure (HF) events in …

Change in Eosinophil Count in Patients with Heart Failure Treated with Anakinra

M Golino, F Moroni, MG Del Buono, JM Canada… - Cells, 2023 - mdpi.com
Background: Interleukin-1 blockade with anakinra leads to a transient increase in eosinophil
blood count (eosinophils) in patients with acute myocardial infarction. We aimed to …

IL-1β is not critical to chronic heart dysfunction in mice with Chagas disease

CV Sousa Oliveira, O Moreno-Loaiza… - Frontiers in …, 2022 - frontiersin.org
Long after Trypanosoma cruzi infection, 40% of individuals develop a progressive chronic
chagasic cardiomyopathy (CCC), with systolic dysfunction and arrhythmias. Since we …

Targeting Inflammation After Myocardial Infarction—Another Piece of the Puzzle

DI Bromage, N Pareek, A Cannata… - Journal of Cardiovascular …, 2022 - journals.lww.com
Coronary artery disease (CAD) is one of the major causes of morbidity and mortality in the
western world. Despite major improvements in treatment in the acute phase, myocardial …

Heart failure in chronic infectious and inflammatory conditions: mechanistic insights from clinical heterogeneity

N Beydoun, MJ Feinstein - Current heart failure reports, 2022 - Springer
Abstract Purpose of Review The balance between inflammation and its resolution plays an
important and increasingly appreciated role in heart failure (HF) pathogenesis. In humans …

Interleukin-1 and Eosinophils in Heart Failure

M Golino - 2023 - irinsubria.uninsubria.it
Background. Anakinra, an IL-1 inhibitor, temporarily increases eosinophil blood levels in
patients with acute myocardial infarction and reduces heart failure (HF) events. Anakinra is …

Joint Application of Multiple Inflammatory Cytokines in Development of Heart Failure

M Yu, Q Zhang, J Zhu, L Xu, L Chen, K Zheng - 2023 - researchsquare.com
Background Heart failure is a serious heart ailment that affects millions of people globally in
terms of their quality of life and general health. In the development and pathophysiology of …

The role and mechanism of NLRP3 inflammasome in chronic heart failure

W Gan, Z Jianghua - J Clin Cardiol, 2023 - lcxxgen.whuhzzs.com
Chronic heart failure (CHF) is the terminal stage of cardiovascular disease. Although the
treatment of CHF has been continuously improved in recent years, there are still high …